TY - JOUR
T1 - Ethnicity as modifier of risk for Vitamin D receptors polymorphisms
T2 - Comprehensive meta-analysis of all cancer sites
AU - Gnagnarella, Patrizia
AU - Raimondi, Sara
AU - Aristarco, Valentina
AU - Johansson, Harriet
AU - Bellerba, Federica
AU - Corso, Federica
AU - De Angelis, Simone Pietro
AU - Belloni, Pietro
AU - Caini, Saverio
AU - Gandini, Sara
N1 - Funding Information:
This work was partially supported by the Italian Ministry of Health with Ricerca Corrente and 5×1000 funds .
Funding Information:
This work was partially supported by the Italian Ministry of Health with Ricerca Corrente and 5?1000 funds.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/2
Y1 - 2021/2
N2 - Vitamin D receptors polymorphisms are found to be associated with several cancers. Since their prevalence vary across ethnicities and ethnicity itself seems to influence the cancer risk, a comprehensive meta-analysis was performed to investigate the role of VDR Fok1, Bsm1, Taq1, Apa1, Cdx2 and cancer risk at specific organ sites. Odds ratios, calculated with random-effects models, summarized one-hundred-ninety-two independent studies for twenty-two cancer sites. Evidence was provided that Fok1, Bsm1, Cdx2, Apa1 and Taq1 are linked to cancer susceptibility for colorectal, lung, ovarian, skin, multiple myeloma and brain cancer. Stratifying by ethnicity, some differences were found, partially explained by minor allele frequency (MAF), for colorectal cancer, ovarian and prostate cancer in Caucasian and prostate cancer in Asian populations. In summary, ethnicity may be a modifier of cancer risk, in particular for hormone dependent cancers and it should be considered evaluating the effect of VDR on cancer risk.
AB - Vitamin D receptors polymorphisms are found to be associated with several cancers. Since their prevalence vary across ethnicities and ethnicity itself seems to influence the cancer risk, a comprehensive meta-analysis was performed to investigate the role of VDR Fok1, Bsm1, Taq1, Apa1, Cdx2 and cancer risk at specific organ sites. Odds ratios, calculated with random-effects models, summarized one-hundred-ninety-two independent studies for twenty-two cancer sites. Evidence was provided that Fok1, Bsm1, Cdx2, Apa1 and Taq1 are linked to cancer susceptibility for colorectal, lung, ovarian, skin, multiple myeloma and brain cancer. Stratifying by ethnicity, some differences were found, partially explained by minor allele frequency (MAF), for colorectal cancer, ovarian and prostate cancer in Caucasian and prostate cancer in Asian populations. In summary, ethnicity may be a modifier of cancer risk, in particular for hormone dependent cancers and it should be considered evaluating the effect of VDR on cancer risk.
KW - Cancer
KW - Ethnicity
KW - Meta-analysis
KW - Polymorphisms
KW - Review
KW - VDR
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=85098961979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85098961979&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2020.103202
DO - 10.1016/j.critrevonc.2020.103202
M3 - Review article
C2 - 33387627
AN - SCOPUS:85098961979
VL - 158
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
M1 - 103202
ER -