Ethylene-oxide and steam-sterilised polysulfone membrane in dialysis patients with eosinophilia

A. Santoro, G. Ferrari, A. Francioso, P. Zucchelli, E. Duranti, M. Sasdelli, A. Rosati, M. Salvadori, G. M. Sanna, M. Briganti, M. Fusaroli, G. Lindner, A. Stefani, P. Borgatti, F. Badiali, R. Mignani, L. Cagnoli, F. Aucella, C. Stallone, M. MassazzaM. Borghi, L. Gualandris, S. Modoni, E. Grandone, M. Margaglione, L. Scatizzi, G. Orlandini

Research output: Contribution to journalArticle

Abstract

Eosinophilia and some acute dialysis side-effects, such as itching, flushing and bronchospasm, are often associated with the presence of ethylene oxide (ETO) as dialyzer sterilizing agent. This study evaluated the effects of two different polysulfone (PS) hollow-fiber dialysers sterilized with ETO and steam in 31 chronic dialysis patients with eosinolphilia. Clinical symptoms, metabolic and biochemical parameters, complement (C3a and C5a) activation and production were evaluated in each patient dialysed for two months at a time with Cuprophan dialyser, ETO-PS dialyser and steam-PS dialyser. The steam-sterilizer agent does not alter the purifying capacity of the PS membrane which maintains its superiority over Cuprophan in terms of biocompatibility. Using steam-PS, intradialytic eosinophil kinetics seems to improve. In some patients with high serum levels of ETO-specific IgE these levels tend to diminish. Generic intradialytic symptoms do not differ between the two sterilization methods, although some hypersensitivity symptoms during the first dialysis hour are considerably lower in some patients when steam-sterilized PS is used. (Int J Artif Organs 1996; 19: 329-35).

Original languageEnglish
Pages (from-to)329-335
Number of pages7
JournalInternational Journal of Artificial Organs
Volume19
Issue number6
Publication statusPublished - 1996

Keywords

  • Biocompatibility
  • Eosinophilia
  • Ethilene-oxide
  • Hemodialysis
  • Hypersensitivity
  • Polysulfone
  • Steam

ASJC Scopus subject areas

  • Biophysics

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  • Cite this

    Santoro, A., Ferrari, G., Francioso, A., Zucchelli, P., Duranti, E., Sasdelli, M., Rosati, A., Salvadori, M., Sanna, G. M., Briganti, M., Fusaroli, M., Lindner, G., Stefani, A., Borgatti, P., Badiali, F., Mignani, R., Cagnoli, L., Aucella, F., Stallone, C., ... Orlandini, G. (1996). Ethylene-oxide and steam-sterilised polysulfone membrane in dialysis patients with eosinophilia. International Journal of Artificial Organs, 19(6), 329-335.