Etiological factors of chronic hepatitis in Italy: A 2014 national survey

Tommaso Stroffolini, Evangelista Sagnelli, Piero L. Almasio, Angelo Andriulli, Antonina Smedile, Mario Pirisi, Caterina Sagnelli, Maurizio Russello, Nicola Coppola, Massimo De Luca, Mariantonietta Pisaturo, Floriano Rosina, Giovanni B. Gaeta

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1%). However, this prevalence was lower (P<0.01) than the corresponding figure (76.5%) for 2001. The proportion of hepatitis B virus-related cases almost doubled over time from 12.2% in 2001 to 22.5% in 2014 (P<0.01), most probably biased because of the distribution of entecavir and tenofovir free of charge at outpatient hospital clinics after 2001. Patients reporting risky alcohol intake (also with other etiologies) accounted for 12.4% of cases, a figure lower than that reported in 2001: 19.2% (P<0.01). The proportion of nonalcoholic fatty liver disease cases nearly doubled over time (3.6% in 2001 and 6.2% in 2014; P<0.05), reflecting the greater attention over time devoted to this syndrome. Conclusion The decreasing role of HCV infection as an etiologic factor of CH in Italy is good news considering the high cost of the directly acting antiviral agents for HCV eradication. Metabolic factors warrant greater attention in the near future.

Original languageEnglish
Pages (from-to)994-997
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume29
Issue number9
DOIs
Publication statusPublished - Jan 1 2017

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Chronic Hepatitis
Italy
Hepacivirus
Tenofovir
Virus Diseases
Hospital Outpatient Clinics
Sex Ratio
Islands
Hepatitis B virus
Antiviral Agents
Alcohols
Surveys and Questionnaires
Costs and Cost Analysis
Liver

Keywords

  • chronic hepatitis
  • hepatitis C virus infection
  • metabolic syndrome
  • nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Etiological factors of chronic hepatitis in Italy : A 2014 national survey. / Stroffolini, Tommaso; Sagnelli, Evangelista; Almasio, Piero L.; Andriulli, Angelo; Smedile, Antonina; Pirisi, Mario; Sagnelli, Caterina; Russello, Maurizio; Coppola, Nicola; De Luca, Massimo; Pisaturo, Mariantonietta; Rosina, Floriano; Gaeta, Giovanni B.

In: European Journal of Gastroenterology and Hepatology, Vol. 29, No. 9, 01.01.2017, p. 994-997.

Research output: Contribution to journalArticle

Stroffolini, T, Sagnelli, E, Almasio, PL, Andriulli, A, Smedile, A, Pirisi, M, Sagnelli, C, Russello, M, Coppola, N, De Luca, M, Pisaturo, M, Rosina, F & Gaeta, GB 2017, 'Etiological factors of chronic hepatitis in Italy: A 2014 national survey', European Journal of Gastroenterology and Hepatology, vol. 29, no. 9, pp. 994-997. https://doi.org/10.1097/MEG.0000000000000907
Stroffolini, Tommaso ; Sagnelli, Evangelista ; Almasio, Piero L. ; Andriulli, Angelo ; Smedile, Antonina ; Pirisi, Mario ; Sagnelli, Caterina ; Russello, Maurizio ; Coppola, Nicola ; De Luca, Massimo ; Pisaturo, Mariantonietta ; Rosina, Floriano ; Gaeta, Giovanni B. / Etiological factors of chronic hepatitis in Italy : A 2014 national survey. In: European Journal of Gastroenterology and Hepatology. 2017 ; Vol. 29, No. 9. pp. 994-997.
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abstract = "Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1{\%}). However, this prevalence was lower (P<0.01) than the corresponding figure (76.5{\%}) for 2001. The proportion of hepatitis B virus-related cases almost doubled over time from 12.2{\%} in 2001 to 22.5{\%} in 2014 (P<0.01), most probably biased because of the distribution of entecavir and tenofovir free of charge at outpatient hospital clinics after 2001. Patients reporting risky alcohol intake (also with other etiologies) accounted for 12.4{\%} of cases, a figure lower than that reported in 2001: 19.2{\%} (P<0.01). The proportion of nonalcoholic fatty liver disease cases nearly doubled over time (3.6{\%} in 2001 and 6.2{\%} in 2014; P<0.05), reflecting the greater attention over time devoted to this syndrome. Conclusion The decreasing role of HCV infection as an etiologic factor of CH in Italy is good news considering the high cost of the directly acting antiviral agents for HCV eradication. Metabolic factors warrant greater attention in the near future.",
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AU - Sagnelli, Evangelista

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AU - Andriulli, Angelo

AU - Smedile, Antonina

AU - Pirisi, Mario

AU - Sagnelli, Caterina

AU - Russello, Maurizio

AU - Coppola, Nicola

AU - De Luca, Massimo

AU - Pisaturo, Mariantonietta

AU - Rosina, Floriano

AU - Gaeta, Giovanni B.

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N2 - Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1%). However, this prevalence was lower (P<0.01) than the corresponding figure (76.5%) for 2001. The proportion of hepatitis B virus-related cases almost doubled over time from 12.2% in 2001 to 22.5% in 2014 (P<0.01), most probably biased because of the distribution of entecavir and tenofovir free of charge at outpatient hospital clinics after 2001. Patients reporting risky alcohol intake (also with other etiologies) accounted for 12.4% of cases, a figure lower than that reported in 2001: 19.2% (P<0.01). The proportion of nonalcoholic fatty liver disease cases nearly doubled over time (3.6% in 2001 and 6.2% in 2014; P<0.05), reflecting the greater attention over time devoted to this syndrome. Conclusion The decreasing role of HCV infection as an etiologic factor of CH in Italy is good news considering the high cost of the directly acting antiviral agents for HCV eradication. Metabolic factors warrant greater attention in the near future.

AB - Background The last Italian prevalence survey on chronic hepatitis (CH) conducted in 2001 showed that the hepatitis C virus (HCV) was the main agent associated with CH. Aim The aim of this study was to evaluate epidemiological changes in CH occurring after 13 years. Patients and methods Enrollment of 1392 CH consecutive patients referred to 16 Italian liver units in 2014 scattered all over the country (four in the North, four in the Center, four in the South, and four in the Islands) was performed. Results The mean age of the patients was 58.3 years, with a sex ratio (male/female) of 1.5. HCV infection (also with other etiologies) continues to be the most prevalent etiology (58.1%). However, this prevalence was lower (P<0.01) than the corresponding figure (76.5%) for 2001. The proportion of hepatitis B virus-related cases almost doubled over time from 12.2% in 2001 to 22.5% in 2014 (P<0.01), most probably biased because of the distribution of entecavir and tenofovir free of charge at outpatient hospital clinics after 2001. Patients reporting risky alcohol intake (also with other etiologies) accounted for 12.4% of cases, a figure lower than that reported in 2001: 19.2% (P<0.01). The proportion of nonalcoholic fatty liver disease cases nearly doubled over time (3.6% in 2001 and 6.2% in 2014; P<0.05), reflecting the greater attention over time devoted to this syndrome. Conclusion The decreasing role of HCV infection as an etiologic factor of CH in Italy is good news considering the high cost of the directly acting antiviral agents for HCV eradication. Metabolic factors warrant greater attention in the near future.

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