Etiology and prognostic implications of a large pericardial effusion in men

A. Colombo, H. G. Olson, J. Egan, J. M. Gardin

Research output: Contribution to journalArticle

Abstract

To assess the etiology and prognosis of a large pericardial effusion, we reviewed 25 consecutive patients who presented with a large pericardial effusion and underwent a drainage procedure. Large pericardial effusion was defined as: (1) an echo-free space ≥ 10 mm anteriorly and posteriorly by M-mode echocardiography and (2) removal of ≥ 350 ml of fluid at pericardial drainage. The etiologies of large pericardial effusion were: neoplastic (36%), idiopathic (32%), uremic (20%), postmyocardial infarction (8%), and acute rheumatic fever (4%). Of our patients, 44% presented with cardiac tamponade, while 25% of patients with idiopathic pericarditis had hemorrhagic effusion and cardiac tamponade. At follow-up, 37 ± 17 months after pericardial drainage, 68% had died from complications of their underlying disease. There were no deaths attributed to pericardial disease. While 88% of patients with idiopathic large pericardial effusion were alive at follow-up, none of the neoplastic large pericardial effusion patients survived longer than 5 months after initial pericardial drainage (p <0.001). Additionally, the survival of patients with uremic large pericardial effusion was better than patients with neoplastic large pericardial effusion (p <0.05). We conclude: (1) neoplastic, idiopathic, and uremic pericarditis are the most common causes of large pericardial effusion in men, (2) idiopathic pericarditis can be hemorrhagic and cause cardiac tamponade, and (3) the prognosis of large pericardial effusion is related to patients' underlying disease.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalClinical Cardiology
Volume11
Issue number6
Publication statusPublished - 1988

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Pericardial Effusion
Cardiac Tamponade
Pericarditis
Drainage
Rheumatic Fever
Infarction
Echocardiography
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Colombo, A., Olson, H. G., Egan, J., & Gardin, J. M. (1988). Etiology and prognostic implications of a large pericardial effusion in men. Clinical Cardiology, 11(6), 389-394.

Etiology and prognostic implications of a large pericardial effusion in men. / Colombo, A.; Olson, H. G.; Egan, J.; Gardin, J. M.

In: Clinical Cardiology, Vol. 11, No. 6, 1988, p. 389-394.

Research output: Contribution to journalArticle

Colombo, A, Olson, HG, Egan, J & Gardin, JM 1988, 'Etiology and prognostic implications of a large pericardial effusion in men', Clinical Cardiology, vol. 11, no. 6, pp. 389-394.
Colombo A, Olson HG, Egan J, Gardin JM. Etiology and prognostic implications of a large pericardial effusion in men. Clinical Cardiology. 1988;11(6):389-394.
Colombo, A. ; Olson, H. G. ; Egan, J. ; Gardin, J. M. / Etiology and prognostic implications of a large pericardial effusion in men. In: Clinical Cardiology. 1988 ; Vol. 11, No. 6. pp. 389-394.
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