Etiology, natural history and treatment of hepatocellular carcinoma

Research output: Contribution to journalArticle


Hepatocellular carcinoma (HCC) is linked to environmental, dietary and lifestyle factors. Patients with cirrhosis and chronic carriage of hepatitis B virus (HBV) are at risk for HCC at annual rates of 3%. HCC risk is particularly high in patients with evidence of cirrhosis and histological markers of increased liver cell proliferation. In addition, thrombocytopenia, prolonged prothrombin time and over 55 years of age also predict the development of HCC. Treatment options are defined according to the presence or absence of cirrhosis, number and size of tumors, and degree of hepatic decompensation. Hepatic resection is the primary intervention for these few patients with tumor but surrounding normal liver tissue and well preserved hepatic function. Under such circumstances, the cumulative 5-year survival is approximately 45%. Liver transplantation (OLT) provides long term survivals (90% at 5 years) in patients with a HCC discovered by chance as a minute nodule and of 75% in patients with viral cirrhosis and a single

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalAntiviral Research
Issue number2
Publication statusPublished - Oct 2003


  • Abdominal ultrasound
  • Alcohol
  • Hepatic resection
  • Liver transplantation
  • Percutaneous interstitial treatments
  • Viral hepatitis

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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