Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy

Simone Longhi; Rachele Bonfiglioli; Laura Obici; Christian Gagliardi; Agnese Milandri; Massimiliano Lorenzini; Pier L uigi Guidalotti; Giampaolo Merlini; Claudio Rapezzi

doi:10.1097/RLU.0000000000000741

Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy

Simone Longhi, Rachele Bonfiglioli, Laura Obici, Christian Gagliardi, Agnese Milandri, Massimiliano Lorenzini, Pier L uigi Guidalotti, Giampaolo Merlini, Claudio Rapezzi

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.

Original language	English
Pages (from-to)	446-447
Number of pages	2
Journal	Clinical Nuclear Medicine
Volume	40
Issue number	5
DOIs	https://doi.org/10.1097/RLU.0000000000000741
Publication status	Published - May 1 2015

ASJC Scopus subject areas

Medicine(all)

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10.1097/RLU.0000000000000741

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title = "Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy",

abstract = "Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease. ",

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T1 - Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy

AU - Longhi, Simone

AU - Bonfiglioli, Rachele

AU - Obici, Laura

AU - Gagliardi, Christian

AU - Milandri, Agnese

AU - Lorenzini, Massimiliano

AU - Guidalotti, Pier L uigi

AU - Merlini, Giampaolo

AU - Rapezzi, Claudio

PY - 2015/5/1

Y1 - 2015/5/1

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AB - Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.

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Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy

Abstract

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