TY - JOUR
T1 - Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy
AU - Longhi, Simone
AU - Bonfiglioli, Rachele
AU - Obici, Laura
AU - Gagliardi, Christian
AU - Milandri, Agnese
AU - Lorenzini, Massimiliano
AU - Guidalotti, Pier L uigi
AU - Merlini, Giampaolo
AU - Rapezzi, Claudio
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.
AB - Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.
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U2 - 10.1097/RLU.0000000000000741
DO - 10.1097/RLU.0000000000000741
M3 - Article
C2 - 25742226
AN - SCOPUS:84946226010
VL - 40
SP - 446
EP - 447
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 5
ER -