Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy

Simone Longhi, Rachele Bonfiglioli, Laura Obici, Christian Gagliardi, Agnese Milandri, Massimiliano Lorenzini, Pier L uigi Guidalotti, Giampaolo Merlini, Claudio Rapezzi

Research output: Contribution to journalArticle

Abstract

Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.

Original languageEnglish
Pages (from-to)446-447
Number of pages2
JournalClinical Nuclear Medicine
Volume40
Issue number5
DOIs
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy'. Together they form a unique fingerprint.

  • Cite this

    Longhi, S., Bonfiglioli, R., Obici, L., Gagliardi, C., Milandri, A., Lorenzini, M., Guidalotti, P. L. U., Merlini, G., & Rapezzi, C. (2015). Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy. Clinical Nuclear Medicine, 40(5), 446-447. https://doi.org/10.1097/RLU.0000000000000741