Etiology of and risk factors for transient and persistent aminotransferase elevation in a population of virus-free blood donors: A multicentre study

Filomena Morisco, Tommaso Stroffolini, Alfonso Mele, Gloria Taliani, Antonina Smedile, Stefania Caronna, Maria E. Tosti, Grazia Niro, Massimo Levrero, Maria T. Fiorillo, Daniela C. Amoruso, Antonio Ascione, Nicola Caporaso

Research output: Contribution to journalArticle

Abstract

Aim: We evaluated the etiology and risk factors for transient and persistently elevated aspartate and/or alanine aminotransferase levels in virus-free blood donors. Methods: Inclusion criteria: HBsAg/HBV-DNA and anti-HCV/HCV-RNA negative blood donors with elevated aspartate aminotransferase and/or alanine aminotransferase, observed in 5 blood transfusion centres in Italy from 2004 to 2005. Aspartate aminotransferase/alanine aminotransferase levels were measured at entry and every 2 months during a period of 6 months. Results: 291 individuals were evaluated (144 with persistent and 147 with transient abnormal aminotransferases). High body mass index was the most frequent (75.5%) etiological factor and was more common in the persistent elevated levels group, compared to the transient elevated levels group (82.0% vs 65.3%; p2 units/day) was reported in 23.6%, with no differences between the two groups. Instead, recent use of medication or paint exposure were most frequently associated with transient elevated levels than persistent elevated levels (61.6% vs 23.3% for drugs and 13.7% vs 4.3% for paint, p29.9). Conclusions: In virus-free blood donors, excessive body mass index is the most frequent etiological factor of abnormal aminotransferases and it is the sole risk factor associated with persistently elevated aminotransferases.

Original languageEnglish
Pages (from-to)441-445
Number of pages5
JournalDigestive and Liver Disease
Volume42
Issue number6
DOIs
Publication statusPublished - Jun 2010

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Keywords

  • Aminotransferase
  • Blood donors
  • Chronic hepatitis
  • Non-alcoholic steatohepatitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology
  • Medicine(all)

Cite this

Morisco, F., Stroffolini, T., Mele, A., Taliani, G., Smedile, A., Caronna, S., Tosti, M. E., Niro, G., Levrero, M., Fiorillo, M. T., Amoruso, D. C., Ascione, A., & Caporaso, N. (2010). Etiology of and risk factors for transient and persistent aminotransferase elevation in a population of virus-free blood donors: A multicentre study. Digestive and Liver Disease, 42(6), 441-445. https://doi.org/10.1016/j.dld.2009.06.017