Experimental models of the disease, as experimental allergic encephalitis (EAE), a virus-induced demyelination, and several clinical and laboratory data suggest that MS is a multifactorial disease in which one or more environmental factors contribute to trigger an immune response directed against myelin antigens in genetically susceptible subjects. From a pathogenic point of view it is important to consider: genetic, viral and immunological factors. Recently many researchers cast doubt on the classification of MS as an autoimmune disease suggesting that a chronic cerebrospinal venous insufficiency (CCSVI) plays a role in the cause of MS.
|Title of host publication||Neuropsychiatric Dysfunction in Multiple Sclerosis|
|Publisher||Springer-Verlag Italia s.r.l.|
|Number of pages||5|
|ISBN (Print)||9788847026766, 884702675X, 9788847026759|
|Publication status||Published - May 1 2012|
ASJC Scopus subject areas