Etiopathogenesis of Gastric Cancer

Giovanni Corso, Daniele Marrelli, Franco Roviello

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The introduction of molecular biology into cancer genetics has resulted in the clarification of several crucial aspects in the etiopathogenesis and tumorigenesis of human cancer. However, gastric cancer continues to represent a clinical burden because of its unfavorable prognosis and our poor knowledge of the molecular mechanisms responsible for the early steps in the initiation of gastric tumor development. Progress has been made through the elucidation of different molecular signaling cascades, such as the mitogen-activated protein kinase cascade, in which the mutator phenotype has been ascribed to a deficiency of the mismatch repair system. While this and similar recent discoveries are still being discussed with respect to their scientific implications, it may nonetheless be appropriate to consider potential clinical applications in the management of patients with gastric cancer.

Original languageEnglish
Title of host publicationSurgery in the Multimodal Management of Gastric Cancer
PublisherSpringer-Verlag Italia s.r.l.
Pages9-14
Number of pages6
Volume9788847023185
ISBN (Print)9788847023185, 8847023173, 9788847023178
DOIs
Publication statusPublished - Nov 1 2012

Keywords

  • E-cadherin
  • EGFR
  • Gastric cancer
  • Helicobacter pylori
  • KRAS
  • MAPK cascade
  • Microsatellite instability
  • PIK3CA
  • Prognostic factors
  • Therapy
  • Tobacco consumption

ASJC Scopus subject areas

  • Medicine(all)

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