Etiopathogenetic considerations on a large series of patients with Juvenile ischemic stroke

M. Grasso, P. Cerrato, A. Appiotti, E. Grasso, L. Priano, C. Baima, M. Girando, E. Verdun, B. Bergamasco

Research output: Contribution to journalArticlepeer-review


The aim of the study was to evaluate stroke subtypes and vascular risk factors in consecutive stroke patients aged less than 50 years. Methods. We enrolled 216 (124 males, 92 females) patients, aging between 16 and 50 years, with TIA or ischemic stroke. Our protocol included medical history, cardiac and neurologic examination, assessment of risk factors (hypertension, diabetes, smoking habits), and laboratory tests [detailed lipid profile, including Lp(a)] and homocysteine. Patients underwent transthoracic echocardiography (70%), transesophageal echocardiography (59%),angiography (28%) and angio-MRI (20%), cranial tomography (94 %) and brain MRI (43%). Results. In our cohort stroke occurred in 60% of cases, TIA in 26% and RIND in 14%. The prevalence of ischemic stroke increases progressively with age: we observed only 7 patients (pts) aged less then 20, 19 patients between 20 and 30, 48 patients between 30 and 40,142 patients between 40 and 50 years old. M/F ratio increases progressively with age: females were prevalent under 30 years (53%), while males were prevalent between 40-50 (60%). Stroke subtypes. Cardioembolic stroke was diagnosed in 57 patients (27% of the cases) with the following distribution in the four decades: 58%,

Original languageEnglish
JournalNeurological Sciences
Issue number4 SUPPL.
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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