TY - JOUR
T1 - Etoposide, cisplatin, epirubicin chemotherapy in the treatment of pediatric liver tumors
AU - Casanova, Michela
AU - Massimino, Maura
AU - Ferrari, Andrea
AU - Spreafico, Filippo
AU - Piva, Luigi
AU - Coppa, Jorgelina
AU - Luksch, Roberto
AU - Cefalo, Graziella
AU - Terenziani, Monica
AU - Polastri, Daniela
AU - Bellani, Franca Fossati
AU - Mazzaferro, Vincenzo
PY - 2005/4
Y1 - 2005/4
N2 - To discuss the potential benefit of a chemotherapy regimen including etoposide (etoposide, cisplatin, epirubicin [EPE]), the authors report a single-institutional experience regarding 13 children with hepatoblastoma (HB) and 7 with hepatocellular carcinoma (HCC). Chemotherapy achieved partial response in 8/9 HB and in 4/5 HCC. Eight initially unresectable HB subsequently had liver resection. Event-free survival and overall survival at 5 years were 84 and 88% for HB (non-metastatic cases: 91 and 100%), 29% for HCC. EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB.
AB - To discuss the potential benefit of a chemotherapy regimen including etoposide (etoposide, cisplatin, epirubicin [EPE]), the authors report a single-institutional experience regarding 13 children with hepatoblastoma (HB) and 7 with hepatocellular carcinoma (HCC). Chemotherapy achieved partial response in 8/9 HB and in 4/5 HCC. Eight initially unresectable HB subsequently had liver resection. Event-free survival and overall survival at 5 years were 84 and 88% for HB (non-metastatic cases: 91 and 100%), 29% for HCC. EPE chemotherapy seems to be effective in the treatment of childhood malignant liver tumors. Etoposide could be suggested as part of intensive multidrug regimens for HCC and high-risk HB.
KW - Chemotherapy
KW - Cis platin
KW - Epirubicin
KW - Etoposide
KW - Hepatoblastoma
KW - Hepatocellular carcinoma
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UR - http://www.scopus.com/inward/citedby.url?scp=20944448885&partnerID=8YFLogxK
U2 - 10.1080/08880010590921441
DO - 10.1080/08880010590921441
M3 - Article
C2 - 16020101
AN - SCOPUS:20944448885
VL - 22
SP - 189
EP - 198
JO - Pediatric Hematology and Oncology
JF - Pediatric Hematology and Oncology
SN - 0888-0018
IS - 3
ER -