EUCAST expert rules in antimicrobial susceptibility testing

R. Leclercq, R. Cantón, D. F J Brown, C. G. Giske, P. Heisig, A. P. Macgowan, J. W. Mouton, P. Nordmann, A. C. Rodloff, G. M. Rossolini, C. J. Soussy, M. Steinbakk, T. G. Winstanley, G. Kahlmeter

Research output: Contribution to journalArticlepeer-review

Abstract

EUCAST expert rules have been developed to assist clinical microbiologists and describe actions to be taken in response to specific antimicrobial susceptibility test results. They include recommendations on reporting, such as inferring susceptibility to other agents from results with one, suppression of results that may be inappropriate, and editing of results from susceptible to intermediate or resistant or from intermediate to resistant on the basis of an inferred resistance mechanism. They are based on current clinical and/or microbiological evidence. EUCAST expert rules also include intrinsic resistance phenotypes and exceptional resistance phenotypes, which have not yet been reported or are very rare. The applicability of EUCAST expert rules depends on the MIC breakpoints used to define the rules. Setting appropriate clinical breakpoints, based on treating patients and not on the detection of resistance mechanisms, may lead to modification of some expert rules in the future.

Original languageEnglish
Pages (from-to)141-160
Number of pages20
JournalClinical Microbiology and Infection
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Antimicrobial susceptibility testing
  • Breakpoints
  • EUCAST
  • Expert rules
  • Interpretive reading

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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