EUELC project: A multi-centre, multipurpose study to investigate early stage NSCLC, and to establish a biobank for ongoing collaboration

J. K. Field, T. Liloglou, A. Niaz, J. Bryan, A. Cassidy, J. R. Gosney, T. Giles, C. Brambilla, E. Brambilla, A. Vesin, J. F. Timsit, P. Hainaut, Y. Martinet, J. M. Vignaud, F. B. Thunnissen, C. Prinsen, P. J. Snijders, E. F. Smit, G. Sozzi, L. RozA. Risch, H. D. Becker, J. S. Elborn, N. D. Magee, L. M. Montuenga, M. J. Pajares, M. D. Lozano, K. J. O'Byrne, D. J. Harrison, J. Niklinski, K. Hodaj, D. Moro-Sibilot, H. Nagy Mignotte, P. Yves Brichon, G. Ferretti, N. Morzol, A. Aubert, M. Aubert, F. Arbib, S. Lantuejoul, V. Siroux, J. Balsan, G. Grosdidier, N. Martinet, A. S. Bolijn, M. Wouters, M. A. Van Der Drift, P. N R Dekhuijzen, A. J. Peeters, D. G M Van Den Hurk, B. E A Hol, J. Van Der Mee, Y. Van Aarssen, R. D M Steenbergen, C. J L M Meijer, T. G. Sutedja, R. M. Van Den Berg, C. Kooi, H. A P Brokx, P. E. Postmus, C. Verri, F. Andriani, D. Conte, A. Livio, L. Tavecchio, U. Pastorino, E. Calabrò, G. Calarco, A. Fabbri, H. Bartsch, B. Jäger, P. Schnabel, M. Thomas, H. Dienemann, F. Herth, J. Pfannschmidt, R. Muczenski-Luz, J. R. Fischer, R. Davis, K. G. McManus, T. Lynch, J. Clarke, M. J. Walshaw, S. W. Duffy, L. Heathcote, N. Hodge, P. Plater, D. Smith, R. Zaman, F. O'Connell, V. Young, S. Nicholson, M. Lawler, K. Gately, M. Barr, H. Buckley, A. Ferguson, C. Enright, J. Agorreta, R. Pio, J. J. Zulueta, J. M. Lopez-Picazo, A. Gurpide, U. Montes, W. Torre, J. Laudanski, M. Kozlowski, G. Lapuc, M. Laudańska, L. Chyczewski, E. Chyczewska

Research output: Contribution to journalArticlepeer-review

Abstract

The European Early Lung Cancer (EUELC) project aims to determine if specific genetic alterations occurring in lung carcinogenesis are detectable in the respiratory epithelium. In order to pursue this objective, nonsmall cell lung cancer (NSCLC) patients with a very high risk of developing progressive lung cancer were recruited from 12 centres in eight European countries: France, Germany, southern Ireland, Italy, the Netherlands, Poland, Spain and the UK. In addition, NSCLC patients were followed up every 6 months for 36 months. A European Bronchial Tissue Bank was set up at the University of Liverpool (Liverpool, UK) to optimise the use of biological specimens. The molecular - pathological investigations were subdivided into specific work packages that were delivered by EUELC Partners. The work packages encompassed mutational analysis, genetic instability, methylation profiling, expression profiling utilising immunohistochemistry and chip-based technologies, as well as in-depth analysis of FHIT and RARβ genes, the telomerase catalytic subunit hTERT and genotyping of susceptibility genes in specific pathways. The EUELC project engendered a tremendous collaborative effort, and it enabled the EUELC Partners to establish protocols for assessing molecular biomarkers in early lung cancer with the view to using such biomarkers for early diagnosis and as intermediate end-points in future chemopreventive programmes. Copyright

Original languageEnglish
Pages (from-to)1477-1486
Number of pages10
JournalEuropean Respiratory Journal
Volume34
Issue number6
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Biobank
  • Case control
  • Epidemiology
  • European Early Lung Cancer
  • Genetic alterations
  • Nonsmall cell lung cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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