Eukaryotic cold shock domain proteins: Highly versatile regulators of gene expression

Marija Mihailovich; Cristina Militti; Toni Gabaldón; Fátima Gebauer

doi:10.1002/bies.200900122

Eukaryotic cold shock domain proteins: Highly versatile regulators of gene expression

Marija Mihailovich, Cristina Militti, Toni Gabaldón, Fátima Gebauer

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to posttranscriptional gene regulation. The CSD is an ancient b-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domaincontaining proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.

Original language	English
Pages (from-to)	109-118
Number of pages	10
Journal	BioEssays
Volume	32
Issue number	2
DOIs	https://doi.org/10.1002/bies.200900122
Publication status	Published - 2010

Keywords

CSD
Exosome
Lin-28
S1
Translation initiation factor
UNR
YB-1

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1002/bies.200900122

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AU - Militti, Cristina

AU - Gabaldón, Toni

AU - Gebauer, Fátima

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Eukaryotic cold shock domain proteins: Highly versatile regulators of gene expression

Abstract

Keywords

ASJC Scopus subject areas

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