Abstract
Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to posttranscriptional gene regulation. The CSD is an ancient b-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domaincontaining proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.
Original language | English |
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Pages (from-to) | 109-118 |
Number of pages | 10 |
Journal | BioEssays |
Volume | 32 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- CSD
- Exosome
- Lin-28
- S1
- Translation initiation factor
- UNR
- YB-1
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)