European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

L. Poller, M. Keown, N. Chauhan, A. M H P Van Den Besselaar, A. Tripodi, C. Shiach, J. Jespersen

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Abstract

A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised.

Original languageEnglish
Pages (from-to)667-669
Number of pages3
JournalJournal of Clinical Pathology
Volume58
Issue number6
DOIs
Publication statusPublished - Jun 2005

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International Normalized Ratio
Thromboplastin
Calibration
Multicenter Studies
Rabbits

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95). / Poller, L.; Keown, M.; Chauhan, N.; Van Den Besselaar, A. M H P; Tripodi, A.; Shiach, C.; Jespersen, J.

In: Journal of Clinical Pathology, Vol. 58, No. 6, 06.2005, p. 667-669.

Research output: Contribution to journalArticle

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