European concerted action on anticoagulation. Correction of displayed international normalized ratio on two point-of-care test whole-blood prothrombin time monitors (CoaguChek Mini and TAS PT-NC) by independent international sensitivity index calibration

Leon Poller, Michelle Keown, Nikhil Chauhan, Anton M H P Van Den Besselaar, Armando Tripodi, Caroline Shiach, Jorgen Jespersen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The international normalized ratio (INR) on two widely used point-of-care test (POCT) prothrombin time (PT) monitors (CoaguChek Mini and TAS PT-NC) differed considerably and also differed from the 'true' INR obtained on the same samples using a manual PT and the same species thromboplastin international reference preparation. Agreement between the displayed INR and difference from 'true' INR has been reassessed following an independent international sensitivity index (ISI) calibration of the two systems. The displayed INRs taken at seven centres were compared with 'true' INRs from the same blood donations and INRs based on the resulting ISI. The overall difference between the displayed INRs on the two monitor systems was reduced from 21.0% to 3.5%. The overall difference in mean INR of system A from the 'true' INR was reduced from 19.0% to 9.5% and of system B from 6.8% to 0.3%, but individual centre's results still showed considerable mean INR variability. Differences between overall displayed INR with the two monitor systems have been reduced by an independent multicentre calibration, and agreement with 'true' INR on the same blood samples improved. However, marked variability in mean INR at individual centres remained after ISI correction, which demonstrates the need for external quality control of individual POCT whole-blood PT monitors.

Original languageEnglish
Pages (from-to)944-949
Number of pages6
JournalBritish Journal of Haematology
Volume122
Issue number6
DOIs
Publication statusPublished - Sep 2003

Fingerprint

Point-of-Care Systems
International Normalized Ratio
Prothrombin Time
Hematologic Tests
Calibration
Thromboplastin

Keywords

  • International normalized ratio
  • Multicentre international sensitivity index (ISI)
  • Point-of-care test (POCT) monitors
  • Prothrombin time

ASJC Scopus subject areas

  • Hematology

Cite this

European concerted action on anticoagulation. Correction of displayed international normalized ratio on two point-of-care test whole-blood prothrombin time monitors (CoaguChek Mini and TAS PT-NC) by independent international sensitivity index calibration. / Poller, Leon; Keown, Michelle; Chauhan, Nikhil; Van Den Besselaar, Anton M H P; Tripodi, Armando; Shiach, Caroline; Jespersen, Jorgen.

In: British Journal of Haematology, Vol. 122, No. 6, 09.2003, p. 944-949.

Research output: Contribution to journalArticle

@article{71852b7671e141f993171bf6fa0c77c8,
title = "European concerted action on anticoagulation. Correction of displayed international normalized ratio on two point-of-care test whole-blood prothrombin time monitors (CoaguChek Mini and TAS PT-NC) by independent international sensitivity index calibration",
abstract = "The international normalized ratio (INR) on two widely used point-of-care test (POCT) prothrombin time (PT) monitors (CoaguChek Mini and TAS PT-NC) differed considerably and also differed from the 'true' INR obtained on the same samples using a manual PT and the same species thromboplastin international reference preparation. Agreement between the displayed INR and difference from 'true' INR has been reassessed following an independent international sensitivity index (ISI) calibration of the two systems. The displayed INRs taken at seven centres were compared with 'true' INRs from the same blood donations and INRs based on the resulting ISI. The overall difference between the displayed INRs on the two monitor systems was reduced from 21.0{\%} to 3.5{\%}. The overall difference in mean INR of system A from the 'true' INR was reduced from 19.0{\%} to 9.5{\%} and of system B from 6.8{\%} to 0.3{\%}, but individual centre's results still showed considerable mean INR variability. Differences between overall displayed INR with the two monitor systems have been reduced by an independent multicentre calibration, and agreement with 'true' INR on the same blood samples improved. However, marked variability in mean INR at individual centres remained after ISI correction, which demonstrates the need for external quality control of individual POCT whole-blood PT monitors.",
keywords = "International normalized ratio, Multicentre international sensitivity index (ISI), Point-of-care test (POCT) monitors, Prothrombin time",
author = "Leon Poller and Michelle Keown and Nikhil Chauhan and {Van Den Besselaar}, {Anton M H P} and Armando Tripodi and Caroline Shiach and Jorgen Jespersen",
year = "2003",
month = "9",
doi = "10.1046/j.1365-2141.2003.04521.x",
language = "English",
volume = "122",
pages = "944--949",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "6",

}

TY - JOUR

T1 - European concerted action on anticoagulation. Correction of displayed international normalized ratio on two point-of-care test whole-blood prothrombin time monitors (CoaguChek Mini and TAS PT-NC) by independent international sensitivity index calibration

AU - Poller, Leon

AU - Keown, Michelle

AU - Chauhan, Nikhil

AU - Van Den Besselaar, Anton M H P

AU - Tripodi, Armando

AU - Shiach, Caroline

AU - Jespersen, Jorgen

PY - 2003/9

Y1 - 2003/9

N2 - The international normalized ratio (INR) on two widely used point-of-care test (POCT) prothrombin time (PT) monitors (CoaguChek Mini and TAS PT-NC) differed considerably and also differed from the 'true' INR obtained on the same samples using a manual PT and the same species thromboplastin international reference preparation. Agreement between the displayed INR and difference from 'true' INR has been reassessed following an independent international sensitivity index (ISI) calibration of the two systems. The displayed INRs taken at seven centres were compared with 'true' INRs from the same blood donations and INRs based on the resulting ISI. The overall difference between the displayed INRs on the two monitor systems was reduced from 21.0% to 3.5%. The overall difference in mean INR of system A from the 'true' INR was reduced from 19.0% to 9.5% and of system B from 6.8% to 0.3%, but individual centre's results still showed considerable mean INR variability. Differences between overall displayed INR with the two monitor systems have been reduced by an independent multicentre calibration, and agreement with 'true' INR on the same blood samples improved. However, marked variability in mean INR at individual centres remained after ISI correction, which demonstrates the need for external quality control of individual POCT whole-blood PT monitors.

AB - The international normalized ratio (INR) on two widely used point-of-care test (POCT) prothrombin time (PT) monitors (CoaguChek Mini and TAS PT-NC) differed considerably and also differed from the 'true' INR obtained on the same samples using a manual PT and the same species thromboplastin international reference preparation. Agreement between the displayed INR and difference from 'true' INR has been reassessed following an independent international sensitivity index (ISI) calibration of the two systems. The displayed INRs taken at seven centres were compared with 'true' INRs from the same blood donations and INRs based on the resulting ISI. The overall difference between the displayed INRs on the two monitor systems was reduced from 21.0% to 3.5%. The overall difference in mean INR of system A from the 'true' INR was reduced from 19.0% to 9.5% and of system B from 6.8% to 0.3%, but individual centre's results still showed considerable mean INR variability. Differences between overall displayed INR with the two monitor systems have been reduced by an independent multicentre calibration, and agreement with 'true' INR on the same blood samples improved. However, marked variability in mean INR at individual centres remained after ISI correction, which demonstrates the need for external quality control of individual POCT whole-blood PT monitors.

KW - International normalized ratio

KW - Multicentre international sensitivity index (ISI)

KW - Point-of-care test (POCT) monitors

KW - Prothrombin time

UR - http://www.scopus.com/inward/record.url?scp=0141651722&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0141651722&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2141.2003.04521.x

DO - 10.1046/j.1365-2141.2003.04521.x

M3 - Article

C2 - 12956765

AN - SCOPUS:0141651722

VL - 122

SP - 944

EP - 949

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 6

ER -