European Concerted Action on Anticoagulation (ECAA) - The multicentre calibration of rabbit and human ECAA reference thromboplastins

L. Poller, T. W. Barrowcliffe, A. M H P Van Den Besselaar, J. Jespersen, A. Tripodi, D. Houghton

Research output: Contribution to journalArticlepeer-review

Abstract

Two candidate ECAA reference preparations have been calibrated in a multicentre exercise at 14 representative national laboratories to provide reference thromboplastin for a large field study in 16 European countries. Two preparations were required because of the established differences in ISI arising from the two main routes of calibration via rabbit and human IRP. To be comparable with working reagents in everyday use a human plain recombinant reagent of low ISI and a rabbit plain preparation of moderately high ISI were selected. A precise calibration of the two candidate preparations has been achieved with the manual PT technique and an ISI of 0.95 (SE 0.0078) for the human reagent and 1.67 (SE 0.0322) for the rabbit reagent.

Original languageEnglish
Pages (from-to)977-982
Number of pages6
JournalThrombosis and Haemostasis
Volume76
Issue number6
Publication statusPublished - Dec 1996

ASJC Scopus subject areas

  • Hematology

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