TY - JOUR
T1 - European Confederation of Medical Mycology (ECMM) prospective survey of candidaemia
T2 - Report from one Italian region
AU - Tortorano, Anna Maria
AU - Biraghi, E.
AU - Astolfi, A.
AU - Ossi, C.
AU - Tejada, M.
AU - Farina, C.
AU - Perin, S.
AU - Bonaccorso, C.
AU - Cavanna, C.
AU - Raballo, A.
AU - Grossi, A.
AU - Lizioli, A.
AU - Merlino, L.
AU - Arghittu, M.
AU - Agrappi, C.
AU - Bezzi, C.
AU - Bramati, S.
AU - Casella, P.
AU - Ceraminiello, A.
AU - Colombo, L.
AU - Ferrari, L.
AU - Frugoni, S.
AU - Garlaschi, L.
AU - Gialluca, G.
AU - Gualterotti, S.
AU - Lombardi, G.
AU - Mauri, A.
AU - Musmanno, M. G.
AU - Passerini, R.
AU - Pierdomenico, S.
AU - Pinsi, G.
AU - Porri, P.
AU - Rigoni, A. L.
AU - Sala, R.
AU - Saudelli, M.
AU - Spinelli, M.
AU - Sturla, C.
AU - Troupioti, P.
AU - Viola, G.
PY - 2002/8
Y1 - 2002/8
N2 - An ECMM epidemiological prospective survey of candidaemia was performed in one Italian region (Lombardy; population: 8 924 870) by the National Society of Medical Mycology (FIMUA) from September 1997 to December 1999. In total, 569 episodes were reported with an overall rate of 0.38/1000 admissions, 4.4/100 000 patient days. Predisposing factors included presence of an intravascular catheter (89%), antibiotic treatment (88%), surgery (56%), intensive care (45%), solid tumour (28%), steroid treatment (15%), haematological malignancy (7%), HIV infection (6%), fetal immaturity (4%). Mucous membrane colonization preceded candidaemia in 83% of patients. Candida albicans was identified in 58% of cases, followed by Candida parapsilosis (15%), Candida glabrata (13%), Candida tropicalis (6%). Septic shock occurred in 95 patients. Crude mortality was 35%, the highest in C. tropicalis fungaemia (44%), the elderly (64%) and solid tumour cancer patients (43%). Intravascular catheter removal was associated with higher survival rate (71 vs. 47%). This survey underscores the importance of candidaemia in hospital settings.
AB - An ECMM epidemiological prospective survey of candidaemia was performed in one Italian region (Lombardy; population: 8 924 870) by the National Society of Medical Mycology (FIMUA) from September 1997 to December 1999. In total, 569 episodes were reported with an overall rate of 0.38/1000 admissions, 4.4/100 000 patient days. Predisposing factors included presence of an intravascular catheter (89%), antibiotic treatment (88%), surgery (56%), intensive care (45%), solid tumour (28%), steroid treatment (15%), haematological malignancy (7%), HIV infection (6%), fetal immaturity (4%). Mucous membrane colonization preceded candidaemia in 83% of patients. Candida albicans was identified in 58% of cases, followed by Candida parapsilosis (15%), Candida glabrata (13%), Candida tropicalis (6%). Septic shock occurred in 95 patients. Crude mortality was 35%, the highest in C. tropicalis fungaemia (44%), the elderly (64%) and solid tumour cancer patients (43%). Intravascular catheter removal was associated with higher survival rate (71 vs. 47%). This survey underscores the importance of candidaemia in hospital settings.
KW - Candida spp.
KW - Epidemiology
KW - Italy
KW - Nosocomial infection
UR - http://www.scopus.com/inward/record.url?scp=0036676447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036676447&partnerID=8YFLogxK
U2 - 10.1053/jhin.2002.1261
DO - 10.1053/jhin.2002.1261
M3 - Article
C2 - 12183145
AN - SCOPUS:0036676447
VL - 51
SP - 297
EP - 304
JO - Journal of Hospital Infection
JF - Journal of Hospital Infection
SN - 0195-6701
IS - 4
ER -