European Confederation of Medical Mycology (ECMM) prospective survey of candidaemia: Report from one Italian region

Anna Maria Tortorano, E. Biraghi, A. Astolfi, C. Ossi, M. Tejada, C. Farina, S. Perin, C. Bonaccorso, C. Cavanna, A. Raballo, A. Grossi, A. Lizioli, L. Merlino, M. Arghittu, C. Agrappi, C. Bezzi, S. Bramati, P. Casella, A. Ceraminiello, L. ColomboL. Ferrari, S. Frugoni, L. Garlaschi, G. Gialluca, S. Gualterotti, G. Lombardi, A. Mauri, M. G. Musmanno, R. Passerini, S. Pierdomenico, G. Pinsi, P. Porri, A. L. Rigoni, R. Sala, M. Saudelli, M. Spinelli, C. Sturla, P. Troupioti, G. Viola

Research output: Contribution to journalArticlepeer-review


An ECMM epidemiological prospective survey of candidaemia was performed in one Italian region (Lombardy; population: 8 924 870) by the National Society of Medical Mycology (FIMUA) from September 1997 to December 1999. In total, 569 episodes were reported with an overall rate of 0.38/1000 admissions, 4.4/100 000 patient days. Predisposing factors included presence of an intravascular catheter (89%), antibiotic treatment (88%), surgery (56%), intensive care (45%), solid tumour (28%), steroid treatment (15%), haematological malignancy (7%), HIV infection (6%), fetal immaturity (4%). Mucous membrane colonization preceded candidaemia in 83% of patients. Candida albicans was identified in 58% of cases, followed by Candida parapsilosis (15%), Candida glabrata (13%), Candida tropicalis (6%). Septic shock occurred in 95 patients. Crude mortality was 35%, the highest in C. tropicalis fungaemia (44%), the elderly (64%) and solid tumour cancer patients (43%). Intravascular catheter removal was associated with higher survival rate (71 vs. 47%). This survey underscores the importance of candidaemia in hospital settings.

Original languageEnglish
Pages (from-to)297-304
Number of pages8
JournalJournal of Hospital Infection
Issue number4
Publication statusPublished - Aug 2002


  • Candida spp.
  • Epidemiology
  • Italy
  • Nosocomial infection

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases


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