Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 31-39 |
| Number of pages | 9 |
| Journal | Stroke |
| Volume | 52 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2021 |
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European Multicenter Study of ET-COVID-19. / Cagnazzo, Federico; Piotin, Michel; Escalard, Simon; Maier, Benjamin; Ribo, Marc; Requena, Manuel; Pop, Raoul; Hasiu, Anca; Gasparotti, Roberto; Mardighian, Dikran; Piano, Mariangela; Cervo, Amedeo; Eker, Omer Faruk; Durous, Vincent; Sourour, Nader-Antoine; Elhorany, Mahmoud; Zini, Andrea; Simonetti, Luigi; Marcheselli, Simona; Paolo, Nuzzi Nunzio; Houdart, Emmanuel; Guédon, Alexis; Ligot, Noémie; Mine, Benjamin; Consoli, Arturo; Lapergue, Bertrand; Cordona Portela, Pere; Urra, Xabier; Rodriguez, Alejandro; Bolognini, Federico; Lebedinsky, Pablo Ariel; Pasco-Papon, Anne; Godard, Sophie; Marnat, Gaultier; Sibon, Igor; Limbucci, Nicola; Nencini, Patrizia; Nappini, Sergio; Saia, Valentina; Caldiera, Valentina; Romano, Daniele; Frauenfelder, Giulia; Gallesio, Ivan; Gola, Giuliano; Menozzi, Roberto; Genovese, Antonio; Terrana, Alberto; Giorgianni, Andrea; Cappellari, Manuel; Augelli, Raffaele; Invernizzi, Paolo; Pavia, Marco; Lafe, Elvis; Cavallini, Anna; Giossi, Alessia; Besana, Michele; Valvassori, Luca; Macera, Antonio; Castellan, Lucio; Salsano, Giancarlo; Di Caterino, Fortunato; Biondi, Alessandra; Arquizan, Caroline; Lebreuche, Julien; Galvano, Gianluca; Cannella, Alfio; Cosottini, Mirco; Lazzarotti, Guido; Guizzardi, Giuseppe; Stecco, Alessandro; Tassi, Rossana; Bracco, Sandra; Bianchini, Elena; Micieli, Camilla; Pascarella, Rosario; Napoli, Manuela; Causin, Francesco; Desal, Hubert; Cotton, François; Costalat, Vincent; Delvoye, François; Ciccio, Gabriele; Smajda, Stanislas; Redjem, Hocine; Hébert, Solène; Blanc, Raphaël; Mazighi, Mikael; Desilles, Jean-Philippes; Mihoc, Dan; Manisor, Monica; Beaujeux, Rémy; Quenardelle, Véronique; Gheoca, Roxana; Wolff, Valérie; Pero, Guiglielmo; Giuditta, Giussani; Chiara, Ceresa; Riva, Roberto; Cappucci, Matteo; Laubacher, Morgane; Tuttle, Celia; Piergallini, Lorenzo; Turjman, Francis; Clarençon, Frédéric; Shotar, Eimad; Lenck, Stéphanie; Premat, Kevin; Degos, Vincent; Samson, Yves; Rosso, Charlotte; Alamowitch, Sonia; Cirillo, Luigi; Gentile, Mauro; Migliaccio, Ludovica; Isceri, Salvatore; Rossi, Simone; Baldini, Tommaso; Dall’Olio, Massimo; Cellerini, Martino; Saint-Maurice, Jean-Pierre; Civelli, Vittorio; Fantoni, Matteo; Gilles, Naeije; Lise, Jodaïtis; Boris, Lubicz; Elens, Stephanie; Thomas, Bonnet; Adrien, Guenego; Niloufar, Sadeghi; Marc, Van Nuffelen; Maria, Federico Di; Coskun, Oguzhan; Rodesch, Georges; Zimatore, Sergio; Florent, Gariel; Berge, Jérôme; Menegon, Patrice; Barreau, Xavier; Tourdias, Thomas; Olindo, Stéphane; Lucas, Ludovic; Liegey, Jean-Sebastien; Sagnier, Sharmila; Renou, Pauline; Couture, Marie; Debruxelles, Sabrina; Poli, Mathilde; Musacchio, Mariano; Delaitre, Mariette; Padolecchia, Riccardo; Ganci, Giuseppe; Sugo, Annalisa; Stefano, Barbero; Giovanni, Taverna Giacomo; Scoditti, Umberto; Castellini, Paola; Latte, Lilia; Grisendi, Ilaria; Epifani, Enrico; Vizzari, Francesco; Molinaro, Stefano; Nativo, Luca; Vinacci, Gabriele; Bonetti, Bruno; Micheletti, Nicola; Tomelleri, Giampaolo; Zampieri, Piergiuseppe; Plebani, Mauro; Grazioli, Andrea; Ricciardi, Giuseppe Kenneth; Polistena, Alessandra; Alessando, Sgreccia; Sanfilippo, Giuseppina; Persico, Alessandra; Boadu, William; Cuzzoni, Maria Giovanna; Magno, Serena; Toscano, Gianpaolo; Denaro, Maria Federica; Tosi, Piera; Censori, Bruno; Puglisi, Valentina; Vinciguerra, Luisa; De Giuli, Valeria; Mavillo, Nicola; Renieri, Leonardo; Fainardi, Enrico; Vitale, Giovanni; Panagiotis, Primikiris; Charbonnier, Guillaume; Claudio, Moratti; Sallustio, Fabrizio; Wlderk, Andrea; Russo, Riccardo; Bergui, Mauro; Comelli, Chiara; Boghi, Andrea; Moynier, Marinette; Maria Ciceri, Elisa Francesca; Toni, Danilo; Frandon, Julien; Mourand, Isabelle; Gaillard, Nicolas; Mangiafico, Salvatore; Derraz, Imad; Dargazanli, Cyril; Lefevre, Pierre-Henri; Riquelme, Carlos; Gascou, Gregory; Bonafe, Alain.
In: Stroke, Vol. 52, No. 1, 2021, p. 31-39.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - European Multicenter Study of ET-COVID-19
AU - Cagnazzo, Federico
AU - Piotin, Michel
AU - Escalard, Simon
AU - Maier, Benjamin
AU - Ribo, Marc
AU - Requena, Manuel
AU - Pop, Raoul
AU - Hasiu, Anca
AU - Gasparotti, Roberto
AU - Mardighian, Dikran
AU - Piano, Mariangela
AU - Cervo, Amedeo
AU - Eker, Omer Faruk
AU - Durous, Vincent
AU - Sourour, Nader-Antoine
AU - Elhorany, Mahmoud
AU - Zini, Andrea
AU - Simonetti, Luigi
AU - Marcheselli, Simona
AU - Paolo, Nuzzi Nunzio
AU - Houdart, Emmanuel
AU - Guédon, Alexis
AU - Ligot, Noémie
AU - Mine, Benjamin
AU - Consoli, Arturo
AU - Lapergue, Bertrand
AU - Cordona Portela, Pere
AU - Urra, Xabier
AU - Rodriguez, Alejandro
AU - Bolognini, Federico
AU - Lebedinsky, Pablo Ariel
AU - Pasco-Papon, Anne
AU - Godard, Sophie
AU - Marnat, Gaultier
AU - Sibon, Igor
AU - Limbucci, Nicola
AU - Nencini, Patrizia
AU - Nappini, Sergio
AU - Saia, Valentina
AU - Caldiera, Valentina
AU - Romano, Daniele
AU - Frauenfelder, Giulia
AU - Gallesio, Ivan
AU - Gola, Giuliano
AU - Menozzi, Roberto
AU - Genovese, Antonio
AU - Terrana, Alberto
AU - Giorgianni, Andrea
AU - Cappellari, Manuel
AU - Augelli, Raffaele
AU - Invernizzi, Paolo
AU - Pavia, Marco
AU - Lafe, Elvis
AU - Cavallini, Anna
AU - Giossi, Alessia
AU - Besana, Michele
AU - Valvassori, Luca
AU - Macera, Antonio
AU - Castellan, Lucio
AU - Salsano, Giancarlo
AU - Di Caterino, Fortunato
AU - Biondi, Alessandra
AU - Arquizan, Caroline
AU - Lebreuche, Julien
AU - Galvano, Gianluca
AU - Cannella, Alfio
AU - Cosottini, Mirco
AU - Lazzarotti, Guido
AU - Guizzardi, Giuseppe
AU - Stecco, Alessandro
AU - Tassi, Rossana
AU - Bracco, Sandra
AU - Bianchini, Elena
AU - Micieli, Camilla
AU - Pascarella, Rosario
AU - Napoli, Manuela
AU - Causin, Francesco
AU - Desal, Hubert
AU - Cotton, François
AU - Costalat, Vincent
AU - Delvoye, François
AU - Ciccio, Gabriele
AU - Smajda, Stanislas
AU - Redjem, Hocine
AU - Hébert, Solène
AU - Blanc, Raphaël
AU - Mazighi, Mikael
AU - Desilles, Jean-Philippes
AU - Mihoc, Dan
AU - Manisor, Monica
AU - Beaujeux, Rémy
AU - Quenardelle, Véronique
AU - Gheoca, Roxana
AU - Wolff, Valérie
AU - Pero, Guiglielmo
AU - Giuditta, Giussani
AU - Chiara, Ceresa
AU - Riva, Roberto
AU - Cappucci, Matteo
AU - Laubacher, Morgane
AU - Tuttle, Celia
AU - Piergallini, Lorenzo
AU - Turjman, Francis
AU - Clarençon, Frédéric
AU - Shotar, Eimad
AU - Lenck, Stéphanie
AU - Premat, Kevin
AU - Degos, Vincent
AU - Samson, Yves
AU - Rosso, Charlotte
AU - Alamowitch, Sonia
AU - Cirillo, Luigi
AU - Gentile, Mauro
AU - Migliaccio, Ludovica
AU - Isceri, Salvatore
AU - Rossi, Simone
AU - Baldini, Tommaso
AU - Dall’Olio, Massimo
AU - Cellerini, Martino
AU - Saint-Maurice, Jean-Pierre
AU - Civelli, Vittorio
AU - Fantoni, Matteo
AU - Gilles, Naeije
AU - Lise, Jodaïtis
AU - Boris, Lubicz
AU - Elens, Stephanie
AU - Thomas, Bonnet
AU - Adrien, Guenego
AU - Niloufar, Sadeghi
AU - Marc, Van Nuffelen
AU - Maria, Federico Di
AU - Coskun, Oguzhan
AU - Rodesch, Georges
AU - Zimatore, Sergio
AU - Florent, Gariel
AU - Berge, Jérôme
AU - Menegon, Patrice
AU - Barreau, Xavier
AU - Tourdias, Thomas
AU - Olindo, Stéphane
AU - Lucas, Ludovic
AU - Liegey, Jean-Sebastien
AU - Sagnier, Sharmila
AU - Renou, Pauline
AU - Couture, Marie
AU - Debruxelles, Sabrina
AU - Poli, Mathilde
AU - Musacchio, Mariano
AU - Delaitre, Mariette
AU - Padolecchia, Riccardo
AU - Ganci, Giuseppe
AU - Sugo, Annalisa
AU - Stefano, Barbero
AU - Giovanni, Taverna Giacomo
AU - Scoditti, Umberto
AU - Castellini, Paola
AU - Latte, Lilia
AU - Grisendi, Ilaria
AU - Epifani, Enrico
AU - Vizzari, Francesco
AU - Molinaro, Stefano
AU - Nativo, Luca
AU - Vinacci, Gabriele
AU - Bonetti, Bruno
AU - Micheletti, Nicola
AU - Tomelleri, Giampaolo
AU - Zampieri, Piergiuseppe
AU - Plebani, Mauro
AU - Grazioli, Andrea
AU - Ricciardi, Giuseppe Kenneth
AU - Polistena, Alessandra
AU - Alessando, Sgreccia
AU - Sanfilippo, Giuseppina
AU - Persico, Alessandra
AU - Boadu, William
AU - Cuzzoni, Maria Giovanna
AU - Magno, Serena
AU - Toscano, Gianpaolo
AU - Denaro, Maria Federica
AU - Tosi, Piera
AU - Censori, Bruno
AU - Puglisi, Valentina
AU - Vinciguerra, Luisa
AU - De Giuli, Valeria
AU - Mavillo, Nicola
AU - Renieri, Leonardo
AU - Fainardi, Enrico
AU - Vitale, Giovanni
AU - Panagiotis, Primikiris
AU - Charbonnier, Guillaume
AU - Claudio, Moratti
AU - Sallustio, Fabrizio
AU - Wlderk, Andrea
AU - Russo, Riccardo
AU - Bergui, Mauro
AU - Comelli, Chiara
AU - Boghi, Andrea
AU - Moynier, Marinette
AU - Maria Ciceri, Elisa Francesca
AU - Toni, Danilo
AU - Frandon, Julien
AU - Mourand, Isabelle
AU - Gaillard, Nicolas
AU - Mangiafico, Salvatore
AU - Derraz, Imad
AU - Dargazanli, Cyril
AU - Lefevre, Pierre-Henri
AU - Riquelme, Carlos
AU - Gascou, Gregory
AU - Bonafe, Alain
PY - 2021
Y1 - 2021
N2 - Background and Purpose: Acute ischemic stroke and large vessel occlusion can be concurrent with the coronavirus disease 2019 (COVID-19) infection. Outcomes after mechanical thrombectomy (MT) for large vessel occlusion in patients with COVID-19 are substantially unknown. Our aim was to study early outcomes after MT in patients with COVID-19. Methods: Multicenter, European, cohort study involving 34 stroke centers in France, Italy, Spain, and Belgium. Data were collected between March 1, 2020 and May 5, 2020. Consecutive laboratory-confirmed COVID-19 cases with large vessel occlusion, who were treated with MT, were included. Primary investigated outcome: 30-day mortality. Secondary outcomes: early neurological improvement (National Institutes of Health Stroke Scale improvement ≥8 points or 24 hours National Institutes of Health Stroke Scale 0–1), successful reperfusion (modified Thrombolysis in Cerebral Infarction grade ≥2b), and symptomatic intracranial hemorrhage. Results: We evaluated 93 patients with COVID-19 with large vessel occlusion who underwent MT (median age, 71 years [interquartile range, 59–79]; 63 men [67.7%]). Median pretreatment National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT Score were 17 (interquartile range, 11–21) and 8 (interquartile range, 7–9), respectively. Anterior circulation acute ischemic stroke represented 93.5% of cases. The rate modified Thrombolysis in Cerebral Infarction 2b to 3 was 79.6% (74 patients [95% CI, 71.3–87.8]). Thirty-day mortality was 29% (27 patients [95% CI, 20–39.4]). Early neurological improvement was 19.5% (17 patients [95% CI, 11.8–29.5]), and symptomatic intracranial hemorrhage was 5.4% (5 patients [95% CI, 1.7–12.1]). Patients who died at 30 days exhibited significantly lower lymphocyte count, higher levels of aspartate, and LDH (lactate dehydrogenase). After adjustment for age, initial National Institutes of Health Stroke Scale, Alberta Stroke Program Early CT Score, and successful reperfusion, these biological markers remained associated with increased odds of 30-day mortality (adjusted odds ratio of 2.70 [95% CI, 1.21–5.98] per SD-log decrease in lymphocyte count, 2.66 [95% CI, 1.22–5.77] per SD-log increase in aspartate, and 4.30 [95% CI, 1.43–12.91] per SD-log increase in LDH). Conclusions: The 29% rate of 30-day mortality after MT among patients with COVID-19 is not negligible. Abnormalities of lymphocyte count, LDH and aspartate may depict a patient’s profiles with poorer outcomes after MT. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT04406090.
AB - Background and Purpose: Acute ischemic stroke and large vessel occlusion can be concurrent with the coronavirus disease 2019 (COVID-19) infection. Outcomes after mechanical thrombectomy (MT) for large vessel occlusion in patients with COVID-19 are substantially unknown. Our aim was to study early outcomes after MT in patients with COVID-19. Methods: Multicenter, European, cohort study involving 34 stroke centers in France, Italy, Spain, and Belgium. Data were collected between March 1, 2020 and May 5, 2020. Consecutive laboratory-confirmed COVID-19 cases with large vessel occlusion, who were treated with MT, were included. Primary investigated outcome: 30-day mortality. Secondary outcomes: early neurological improvement (National Institutes of Health Stroke Scale improvement ≥8 points or 24 hours National Institutes of Health Stroke Scale 0–1), successful reperfusion (modified Thrombolysis in Cerebral Infarction grade ≥2b), and symptomatic intracranial hemorrhage. Results: We evaluated 93 patients with COVID-19 with large vessel occlusion who underwent MT (median age, 71 years [interquartile range, 59–79]; 63 men [67.7%]). Median pretreatment National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT Score were 17 (interquartile range, 11–21) and 8 (interquartile range, 7–9), respectively. Anterior circulation acute ischemic stroke represented 93.5% of cases. The rate modified Thrombolysis in Cerebral Infarction 2b to 3 was 79.6% (74 patients [95% CI, 71.3–87.8]). Thirty-day mortality was 29% (27 patients [95% CI, 20–39.4]). Early neurological improvement was 19.5% (17 patients [95% CI, 11.8–29.5]), and symptomatic intracranial hemorrhage was 5.4% (5 patients [95% CI, 1.7–12.1]). Patients who died at 30 days exhibited significantly lower lymphocyte count, higher levels of aspartate, and LDH (lactate dehydrogenase). After adjustment for age, initial National Institutes of Health Stroke Scale, Alberta Stroke Program Early CT Score, and successful reperfusion, these biological markers remained associated with increased odds of 30-day mortality (adjusted odds ratio of 2.70 [95% CI, 1.21–5.98] per SD-log decrease in lymphocyte count, 2.66 [95% CI, 1.22–5.77] per SD-log increase in aspartate, and 4.30 [95% CI, 1.43–12.91] per SD-log increase in LDH). Conclusions: The 29% rate of 30-day mortality after MT among patients with COVID-19 is not negligible. Abnormalities of lymphocyte count, LDH and aspartate may depict a patient’s profiles with poorer outcomes after MT. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT04406090.
U2 - 10.1161/STROKEAHA.120.031514
DO - 10.1161/STROKEAHA.120.031514
M3 - Article
VL - 52
SP - 31
EP - 39
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 1
ER -