Abstract
Objective - To develop criteria for disease activity in systemic sclerosis (SSc) that are valid, reliable, and easy to use. Methods - Investigators from 19 European centres completed a standardised clinical chart for a consecutive number of patients with SSc. Three protocol management members blindly evaluated each chart and assigned a disease activity score on a semiquantitative scale of 0-10. Two of them, in addition, gave a blinded, qualitative evaluation of disease activity ("inactive to moderately active" or "active to very active" disease). Both these evaluations were found to be reliable. A final disease activity score and qualitative evaluation of disease activity were arrived at by consensus for each patient; the former represented the gold standard for subsequent analyses. The correlations between individual items in the chart and this gold standard were then analysed. Results - A total of 290 patients with SSc (117 with diffuse SSc (dSSc) and 173 with limited SSc (lSSc)) were enrolled in the study. The items (including Δ-factors that is, worsening according to the patient report) that were found to correlate with the gold standard on multiple regression were used to construct three separate 10-point indices of disease activity: (a) Δ-cardiopulmonary (4.0), Δ-skin (3.0), Δ-vascular (2.0), and Δ-articular/muscular (1.0) for patients with dSSc; (b) Δ-skin (2.5), erythrocyte sedimentation rate (ESR) >30 mm/1st h (2.5), Δ-cardiopulmonary (1.5), Δ-vascular (1.0), arthritis (1.0), hypocomplementaemia (1.0), and scleredema (0.5) for lSSc; (c) Δ-cardiopulmonary (2.0), Δ-skin (2.0), ESR >30 mm/1st h (1.5), total skin score >20 (1.0), hypocomplementaemia (1.0), scleredema (0.5), digital necrosis (0.5), Δ-vascular (0.5), arthritis (0.5), TLCO
| Original language | English |
|---|---|
| Pages (from-to) | 592-598 |
| Number of pages | 7 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 60 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2001 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes. / Valentini, G.; Della Rossa, A.; Bombardieri, S.; Bencivelli, W.; Silman, A. J.; D'Angelo, S.; Matucci Cerinic, M.; Belch, J. F.; Black, C. M.; Bruhlmann, P.; Czirják, L.; De Luca, A.; Drosos, A. A.; Ferri, C.; Gabrielli, A.; Giacomelli, R.; Hayem, G.; Inanc, M.; McHugh, N. J.; Nielsen, H.; Rosada, M.; Scorza, R.; Stork, J.; Sysa, A.; Van den Hoogen, F. H J; Vlachoyiannopoulos, P. J.
In: Annals of the Rheumatic Diseases, Vol. 60, No. 6, 2001, p. 592-598.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes
AU - Valentini, G.
AU - Della Rossa, A.
AU - Bombardieri, S.
AU - Bencivelli, W.
AU - Silman, A. J.
AU - D'Angelo, S.
AU - Matucci Cerinic, M.
AU - Belch, J. F.
AU - Black, C. M.
AU - Bruhlmann, P.
AU - Czirják, L.
AU - De Luca, A.
AU - Drosos, A. A.
AU - Ferri, C.
AU - Gabrielli, A.
AU - Giacomelli, R.
AU - Hayem, G.
AU - Inanc, M.
AU - McHugh, N. J.
AU - Nielsen, H.
AU - Rosada, M.
AU - Scorza, R.
AU - Stork, J.
AU - Sysa, A.
AU - Van den Hoogen, F. H J
AU - Vlachoyiannopoulos, P. J.
PY - 2001
Y1 - 2001
N2 - Objective - To develop criteria for disease activity in systemic sclerosis (SSc) that are valid, reliable, and easy to use. Methods - Investigators from 19 European centres completed a standardised clinical chart for a consecutive number of patients with SSc. Three protocol management members blindly evaluated each chart and assigned a disease activity score on a semiquantitative scale of 0-10. Two of them, in addition, gave a blinded, qualitative evaluation of disease activity ("inactive to moderately active" or "active to very active" disease). Both these evaluations were found to be reliable. A final disease activity score and qualitative evaluation of disease activity were arrived at by consensus for each patient; the former represented the gold standard for subsequent analyses. The correlations between individual items in the chart and this gold standard were then analysed. Results - A total of 290 patients with SSc (117 with diffuse SSc (dSSc) and 173 with limited SSc (lSSc)) were enrolled in the study. The items (including Δ-factors that is, worsening according to the patient report) that were found to correlate with the gold standard on multiple regression were used to construct three separate 10-point indices of disease activity: (a) Δ-cardiopulmonary (4.0), Δ-skin (3.0), Δ-vascular (2.0), and Δ-articular/muscular (1.0) for patients with dSSc; (b) Δ-skin (2.5), erythrocyte sedimentation rate (ESR) >30 mm/1st h (2.5), Δ-cardiopulmonary (1.5), Δ-vascular (1.0), arthritis (1.0), hypocomplementaemia (1.0), and scleredema (0.5) for lSSc; (c) Δ-cardiopulmonary (2.0), Δ-skin (2.0), ESR >30 mm/1st h (1.5), total skin score >20 (1.0), hypocomplementaemia (1.0), scleredema (0.5), digital necrosis (0.5), Δ-vascular (0.5), arthritis (0.5), TLCO
AB - Objective - To develop criteria for disease activity in systemic sclerosis (SSc) that are valid, reliable, and easy to use. Methods - Investigators from 19 European centres completed a standardised clinical chart for a consecutive number of patients with SSc. Three protocol management members blindly evaluated each chart and assigned a disease activity score on a semiquantitative scale of 0-10. Two of them, in addition, gave a blinded, qualitative evaluation of disease activity ("inactive to moderately active" or "active to very active" disease). Both these evaluations were found to be reliable. A final disease activity score and qualitative evaluation of disease activity were arrived at by consensus for each patient; the former represented the gold standard for subsequent analyses. The correlations between individual items in the chart and this gold standard were then analysed. Results - A total of 290 patients with SSc (117 with diffuse SSc (dSSc) and 173 with limited SSc (lSSc)) were enrolled in the study. The items (including Δ-factors that is, worsening according to the patient report) that were found to correlate with the gold standard on multiple regression were used to construct three separate 10-point indices of disease activity: (a) Δ-cardiopulmonary (4.0), Δ-skin (3.0), Δ-vascular (2.0), and Δ-articular/muscular (1.0) for patients with dSSc; (b) Δ-skin (2.5), erythrocyte sedimentation rate (ESR) >30 mm/1st h (2.5), Δ-cardiopulmonary (1.5), Δ-vascular (1.0), arthritis (1.0), hypocomplementaemia (1.0), and scleredema (0.5) for lSSc; (c) Δ-cardiopulmonary (2.0), Δ-skin (2.0), ESR >30 mm/1st h (1.5), total skin score >20 (1.0), hypocomplementaemia (1.0), scleredema (0.5), digital necrosis (0.5), Δ-vascular (0.5), arthritis (0.5), TLCO
UR - http://www.scopus.com/inward/record.url?scp=0035020571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035020571&partnerID=8YFLogxK
U2 - 10.1136/ard.60.6.592
DO - 10.1136/ard.60.6.592
M3 - Article
C2 - 11350848
AN - SCOPUS:0035020571
VL - 60
SP - 592
EP - 598
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 6
ER -