European population substructure: clustering of northern and southern populations.

Michael F. Seldin, Russell Shigeta, Pablo Villoslada, Carlo Selmi, Jaakko Tuomilehto, Gabriel Silva, John W. Belmont, Lars Klareskog, Peter K. Gregersen

Research output: Contribution to journalArticle

Abstract

Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there is a consistent and reproducible distinction between "northern" and "southern" European population groups: most individual participants with southern European ancestry (Italian, Spanish, Portuguese, and Greek) have >85% membership in the "southern" population; and most northern, western, eastern, and central Europeans have >90% in the "northern" population group. Ashkenazi Jewish as well as Sephardic Jewish origin also showed >85% membership in the "southern" population, consistent with a later Mediterranean origin of these ethnic groups. Based on this work, we have developed a core set of informative SNP markers that can control for this partition in European population structure in a variety of clinical and genetic studies.

Original languageEnglish
JournalPLoS Genetics
Volume2
Issue number9
DOIs
Publication statusPublished - Sep 15 2006

Fingerprint

population structure
Cluster Analysis
polymorphism
ethnic group
Population Groups
ancestry
single nucleotide polymorphism
Population
Single Nucleotide Polymorphism
genome
nationalities and ethnic groups
Ethnic Groups
Genome
testing
marker
test

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics
  • Cancer Research
  • Genetics(clinical)

Cite this

Seldin, M. F., Shigeta, R., Villoslada, P., Selmi, C., Tuomilehto, J., Silva, G., ... Gregersen, P. K. (2006). European population substructure: clustering of northern and southern populations. PLoS Genetics, 2(9). https://doi.org/10.1371/journal.pgen.0020143

European population substructure : clustering of northern and southern populations. / Seldin, Michael F.; Shigeta, Russell; Villoslada, Pablo; Selmi, Carlo; Tuomilehto, Jaakko; Silva, Gabriel; Belmont, John W.; Klareskog, Lars; Gregersen, Peter K.

In: PLoS Genetics, Vol. 2, No. 9, 15.09.2006.

Research output: Contribution to journalArticle

Seldin, MF, Shigeta, R, Villoslada, P, Selmi, C, Tuomilehto, J, Silva, G, Belmont, JW, Klareskog, L & Gregersen, PK 2006, 'European population substructure: clustering of northern and southern populations.', PLoS Genetics, vol. 2, no. 9. https://doi.org/10.1371/journal.pgen.0020143
Seldin, Michael F. ; Shigeta, Russell ; Villoslada, Pablo ; Selmi, Carlo ; Tuomilehto, Jaakko ; Silva, Gabriel ; Belmont, John W. ; Klareskog, Lars ; Gregersen, Peter K. / European population substructure : clustering of northern and southern populations. In: PLoS Genetics. 2006 ; Vol. 2, No. 9.
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