European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials

Lisa Vermunt, Colin D Veal, Lea Ter Meulen, Charalambos Chrysostomou, Wiesje van der Flier, Giovanni B Frisoni, Idris Guessous, Miia Kivipelto, Moira Marizzoni, Pablo Martinez-Lage, José Luis Molinuevo, David Porteous, Karen Ritchie, Philip Scheltens, Pierre-Jean Ousset, Craig W Ritchie, Gerald Luscan, Anthony J Brookes, Pieter Jelle Visser

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: It is a challenge to find participants for Alzheimer's disease (AD) prevention trials within a short period of time. The European Prevention of Alzheimer's Dementia Registry (EPAD) aims to facilitate recruitment by preselecting subjects from ongoing cohort studies. This article introduces this novel approach.

METHODS: A virtual registry, with access to risk factors and biomarkers for AD through minimal data sets of ongoing cohort studies, was set up.

RESULTS: To date, ten cohorts have been included in the EPAD. Around 2500 participants have been selected, using variables associated with the risk for AD. Of these, 15% were already recruited in the EPAD longitudinal cohort study, which serves as a trial readiness cohort.

DISCUSSION: This study demonstrates that a virtual registry can be used for the preselection of participants for AD studies.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalAlzheimer's and Dementia
Volume14
Issue number6
DOIs
Publication statusPublished - Jun 2018

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