European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms

K A Rack, E van den Berg, C Haferlach, H B Beverloo, D Costa, B Espinet, N Foot, S Jeffries, K Martin, S O'Connor, J Schoumans, P Talley, N Telford, S Stioui, Z Zemanova, R J Hastings

Research output: Contribution to journalReview articlepeer-review


Cytogenomic investigations of haematological neoplasms, including chromosome banding analysis, fluorescence in situ hybridisation (FISH) and microarray analyses have become increasingly important in the clinical management of patients with haematological neoplasms. The widespread implementation of these techniques in genetic diagnostics has highlighted the need for guidance on the essential criteria to follow when providing cytogenomic testing, regardless of choice of methodology. These recommendations provide an updated, practical and easily available document that will assist laboratories in the choice of testing and methodology enabling them to operate within acceptable standards and maintain a quality service.

Original languageEnglish
Pages (from-to)1851-1867
Number of pages17
Issue number8
Publication statusPublished - Aug 2019


  • Chromosome Banding
  • Hematologic Neoplasms/genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Leukemia, Myeloid, Acute/genetics
  • Lymphoma/genetics
  • Microarray Analysis
  • Multiple Myeloma/genetics
  • Myelodysplastic Syndromes


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