European registry of babies born to mothers with antiphospholipid syndrome

Arsene Mekinian, Eric Lachassinne, Pascale Nicaise-Roland, Lionel Carbillon, Mario Motta, Eric Vicaut, Catherine Boinot, Tadej Avcin, Philippe Letoumelin, Sara De Carolis, Patrizia Rovere-Querini, Marc Lambert, Sophie Derenne, Olivier Pourrat, Jerome Stirnemann, Sylvie Chollet-Martin, Chiara Biasini-Rebaioli, Rosanna Rovelli, Andrea Lojacono, Ales AmbrozicAngela Botta, Amelie Benbara, Fabrice Pierre, Flavio Allegri, Monica Nuzzo, Pierre Yves Hatron, Angela Tincani, Olivier Fain, Marie Helene Aurousseau, Marie Claire Boffa

Research output: Contribution to journalArticlepeer-review


Objectives: This study aimed to describe the long-term outcome and immunological status of children born to mothers with antiphospholipid syndrome, to determine the factors responsible for childhood abnormalities, and to correlate the child's immunological profile with their mothers. Methods: A prospective follow-up of a European multicentre cohort was conducted. The follow-up consisted of clinical examination, growth data, neurodevelopmental milestones and antiphospholipid antibodies (APL) screening. Children were examined at 3, 9, 24 months and 5 years. Results: 134 children were analysed (female sex in 65 cases, birth weight 3000±500 g, height 48±3 cm). Sixteen per cent had a preterm birth (2 glycoprotein-I (anti-β2GPI) IgG/M in 16 (15%) and three (3%), respectively. ACL IgG and anti-β2GPI disappeared at 6 months in nine (17%) and nine (18%), whereas APL persisted in 10% of children. ACL and anti-β2GPI IgG were correlated with the same mother's antibodies before 6 months of age (p

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalAnnals of the Rheumatic Diseases
Issue number2
Publication statusPublished - Feb 2013

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy


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