European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer

Giulia Bertino, Gregor Sersa, Francesca De Terlizzi, Antonio Occhini, Christina Caroline Plaschke, Ales Groselj, Cristobal Langdon, Juan J. Grau, James A. McCaul, Derrek Heuveling, Maja Cemazar, Primoz Strojan, Remco De Bree, C. Renè Leemans, Irene Wessel, Julie Gehl, Marco Benazzo

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Electrochemotherapy is an effective and safe method for local treatment of cutaneous and subcutaneous tumours, where electric pulses cause increased permeability of cell membranes in the tumour mass, enabling dramatically enhanced effectiveness of bleomycin and other hydrophilic drugs. Here, we report results of a European multi-institutional prospective study of the effectiveness of electrochemotherapy in the treatment of skin cancer of the head and neck (HN) area, where standard treatments had either failed or were not deemed suitable or declined by the patient. A total of 105 patients affected by primary or recurrent skin cancer of the HN area were enrolled; of these, 99 were eligible for evaluation of tumour response. By far, the majority (82%) were treated only once, and 18% of patients had a second treatment. The objective response was highest for basal cell carcinoma (97%) and for other histologies was 74%. Small, primary, and treatment-naive carcinomas responded significantly better (p <0.05), as investigated by univariate analysis. Electrochemotherapy was well tolerated and led to a significant improvement of quality of life, estimated by the European Organisation for Research and Treatment of Cancer quality of life questionnaires. At 1-year follow-up, the percentages of overall and disease-free survival were 76% and 89%, respectively. Electrochemotherapy is an effective option for skin cancers of the HN area and can be considered a feasible alternative to standard treatments when such an alternative is appropriate. The precise role for electrochemotherapy in the treatment algorithm for non-melanoma skin cancer of the HN region requires data from future randomised controlled studies. (ISRCTN registry N. 30427)

Original languageEnglish
Pages (from-to)41-52
Number of pages12
JournalEuropean Journal of Cancer
Volume63
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Electrochemotherapy
Skin Neoplasms
Head and Neck Neoplasms
Research
Quality of Life
Therapeutics
Cell Membrane Permeability
Neoplasms
Basal Cell Carcinoma
Bleomycin
Disease-Free Survival
Registries
Histology
Prospective Studies
Carcinoma
Skin

Keywords

  • Basal cell carcinoma
  • Electrochemotherapy
  • Head and neck
  • Malignant melanoma
  • Quality of life
  • Squamous cell carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project : Results of the treatment of skin cancer. / Bertino, Giulia; Sersa, Gregor; De Terlizzi, Francesca; Occhini, Antonio; Plaschke, Christina Caroline; Groselj, Ales; Langdon, Cristobal; Grau, Juan J.; McCaul, James A.; Heuveling, Derrek; Cemazar, Maja; Strojan, Primoz; De Bree, Remco; Leemans, C. Renè; Wessel, Irene; Gehl, Julie; Benazzo, Marco.

In: European Journal of Cancer, Vol. 63, 01.08.2016, p. 41-52.

Research output: Contribution to journalArticle

Bertino, G, Sersa, G, De Terlizzi, F, Occhini, A, Plaschke, CC, Groselj, A, Langdon, C, Grau, JJ, McCaul, JA, Heuveling, D, Cemazar, M, Strojan, P, De Bree, R, Leemans, CR, Wessel, I, Gehl, J & Benazzo, M 2016, 'European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project: Results of the treatment of skin cancer', European Journal of Cancer, vol. 63, pp. 41-52. https://doi.org/10.1016/j.ejca.2016.05.001
Bertino, Giulia ; Sersa, Gregor ; De Terlizzi, Francesca ; Occhini, Antonio ; Plaschke, Christina Caroline ; Groselj, Ales ; Langdon, Cristobal ; Grau, Juan J. ; McCaul, James A. ; Heuveling, Derrek ; Cemazar, Maja ; Strojan, Primoz ; De Bree, Remco ; Leemans, C. Renè ; Wessel, Irene ; Gehl, Julie ; Benazzo, Marco. / European Research on Electrochemotherapy in Head and Neck Cancer (EURECA) project : Results of the treatment of skin cancer. In: European Journal of Cancer. 2016 ; Vol. 63. pp. 41-52.
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