Abstract
European epidemiological studies on ambient air pollution and cancer published before December 2006 are reviewed, with focus on five analytic studies providing data on the association between various measures of particulate matter (PM) and lung cancer. A case-control study of 755 men who died from lung cancer in Trieste, Italy, reported that, compared with less than 0.18 g/m/day of deposition of particulate, the relative risk (RR) was 1.1 [95% confidence interval (CI): 0.8-1.5] for 0.18-0.30 and 1.4 (95% CI: 1.1-1.8) for more than 0.30 g/m/day. In the Netherlands Cohort Study on Diet and Cancer with 60 deaths from lung cancer, the RR was 1.06 (95% CI: 0.43-2.63) for an increase of 10 μg/m in black smoke. In the French Pollution Atmospherique et Affections Respiratoires Chroniques study cohort based on 178 deaths from lung cancer, the RR associated with an increase in exposure to 10 μg/m of total suspended particulate was 0.97 (95% CI: 0.94-1.01). A nested case-control study within the European Prospective Investigation on Cancer and Nutrition included 113 nonsmokers or exsmokers diagnosed with lung cancer and 312 controls. The RRs were 0.91 (95% CI: 0.70-1.18) for an increase in PM with diameter ≤10 μm (PM10) of 10 μg/m, and 0.98 (95% CI: 0.66-1.45) for exposure over 27 μg/m compared with less than 27 μg/m. In a Norwegian record linkage study, based on 1453 lung cancer deaths, no significant excess risk was found for men, and a modest association was observed for women. European studies of PM exposure and lung cancer do not show a clear association, but uncertainties remain for the measurement of exposure and latency.
| Original language | English |
|---|---|
| Pages (from-to) | 191-194 |
| Number of pages | 4 |
| Journal | European Journal of Cancer Prevention |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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Keywords
- Air pollution
- Europe
- Lung cancer
- Particulate matter
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
European studies on long-term exposure to ambient particulate matter and lung cancer. / Gallus, Silvano; Negri, Eva; Boffetta, Paolo; McLaughlin, Joseph K.; Bosetti, Cristina; Vecchia, Carlo La.
In: European Journal of Cancer Prevention, Vol. 17, No. 3, 06.2008, p. 191-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - European studies on long-term exposure to ambient particulate matter and lung cancer
AU - Gallus, Silvano
AU - Negri, Eva
AU - Boffetta, Paolo
AU - McLaughlin, Joseph K.
AU - Bosetti, Cristina
AU - Vecchia, Carlo La
PY - 2008/6
Y1 - 2008/6
N2 - European epidemiological studies on ambient air pollution and cancer published before December 2006 are reviewed, with focus on five analytic studies providing data on the association between various measures of particulate matter (PM) and lung cancer. A case-control study of 755 men who died from lung cancer in Trieste, Italy, reported that, compared with less than 0.18 g/m/day of deposition of particulate, the relative risk (RR) was 1.1 [95% confidence interval (CI): 0.8-1.5] for 0.18-0.30 and 1.4 (95% CI: 1.1-1.8) for more than 0.30 g/m/day. In the Netherlands Cohort Study on Diet and Cancer with 60 deaths from lung cancer, the RR was 1.06 (95% CI: 0.43-2.63) for an increase of 10 μg/m in black smoke. In the French Pollution Atmospherique et Affections Respiratoires Chroniques study cohort based on 178 deaths from lung cancer, the RR associated with an increase in exposure to 10 μg/m of total suspended particulate was 0.97 (95% CI: 0.94-1.01). A nested case-control study within the European Prospective Investigation on Cancer and Nutrition included 113 nonsmokers or exsmokers diagnosed with lung cancer and 312 controls. The RRs were 0.91 (95% CI: 0.70-1.18) for an increase in PM with diameter ≤10 μm (PM10) of 10 μg/m, and 0.98 (95% CI: 0.66-1.45) for exposure over 27 μg/m compared with less than 27 μg/m. In a Norwegian record linkage study, based on 1453 lung cancer deaths, no significant excess risk was found for men, and a modest association was observed for women. European studies of PM exposure and lung cancer do not show a clear association, but uncertainties remain for the measurement of exposure and latency.
AB - European epidemiological studies on ambient air pollution and cancer published before December 2006 are reviewed, with focus on five analytic studies providing data on the association between various measures of particulate matter (PM) and lung cancer. A case-control study of 755 men who died from lung cancer in Trieste, Italy, reported that, compared with less than 0.18 g/m/day of deposition of particulate, the relative risk (RR) was 1.1 [95% confidence interval (CI): 0.8-1.5] for 0.18-0.30 and 1.4 (95% CI: 1.1-1.8) for more than 0.30 g/m/day. In the Netherlands Cohort Study on Diet and Cancer with 60 deaths from lung cancer, the RR was 1.06 (95% CI: 0.43-2.63) for an increase of 10 μg/m in black smoke. In the French Pollution Atmospherique et Affections Respiratoires Chroniques study cohort based on 178 deaths from lung cancer, the RR associated with an increase in exposure to 10 μg/m of total suspended particulate was 0.97 (95% CI: 0.94-1.01). A nested case-control study within the European Prospective Investigation on Cancer and Nutrition included 113 nonsmokers or exsmokers diagnosed with lung cancer and 312 controls. The RRs were 0.91 (95% CI: 0.70-1.18) for an increase in PM with diameter ≤10 μm (PM10) of 10 μg/m, and 0.98 (95% CI: 0.66-1.45) for exposure over 27 μg/m compared with less than 27 μg/m. In a Norwegian record linkage study, based on 1453 lung cancer deaths, no significant excess risk was found for men, and a modest association was observed for women. European studies of PM exposure and lung cancer do not show a clear association, but uncertainties remain for the measurement of exposure and latency.
KW - Air pollution
KW - Europe
KW - Lung cancer
KW - Particulate matter
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UR - http://www.scopus.com/inward/citedby.url?scp=42249112400&partnerID=8YFLogxK
U2 - 10.1097/CEJ.0b013e3282f0bfe5
DO - 10.1097/CEJ.0b013e3282f0bfe5
M3 - Article
C2 - 18414188
AN - SCOPUS:42249112400
VL - 17
SP - 191
EP - 194
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
SN - 0959-8278
IS - 3
ER -