European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014

Randy Poelman, Isabelle Schuffenecker, Coretta Van Leer-Buter, Laurence Josset, Hubert G M Niesters, Bruno Lina, Theresia Popow-Kraupp, Stephan W. Aberle, Thea Kølsen Fischer, Sofie Midgley, Claus Bohn Christiansen, Matti Waris, Riikka österback, Tytti Vuorinen, Carita Savolainen-Kopra, Francesca Latronico, Soile Blomqvist, Niina Ikonen, Maija Lappalainen, Anne JääskeläinenTeemu Smura, Léa Pilorge, Marie Christine Legrand-Quillien, Christopher Payan, Joëlle Petitjean, Astrid Vabret, Mélanie Ribault, Audrey Mirand, Hélène Peigue-Lafeuille, Cécile Henquell, Catherine Manoha, Jean Baptiste Bour, Magali Darniot, Jérôme Le Goff, Séverine Mercier-Delarue, Catherine Scieux, Sylvie Pillet, Bruno Pozzetto, Quentin Lepiller, Samira Fafi-Kremer, Françoise Stoll-Keller, Stéphanie Marque-Juillet, Aymeric Coutard, Marlène Amara, Sindy Böttcher, Sabine Diedrich, Anna Maria Eis-Hübinger, Souhaib Aldabbagh, Ulrike Reber, Marcus Panning, Daniela Huzly, Sibylle Bierbaum, Uwe G. Liebert, Melanie Maier, Michael J. Carr, Gráinne Tuite, Jorge Abboud Guerra, Joanne O'Gorman, Cillian De Gascun, Fausto Baldanti, Antonio Piralla, Susanna Esposito, Nicola Principi, Luca Ruggiero, Matthias Opp, Gé Donker, Adam Meijer, Harrie van der Avoort, Kimberley Benschop, Marit de Lange, Hubert Niesters, Renze Borger, Liesbeth Scholvinck, Wil van der Reijden, Dick Veenendaal, Eric C J Claas, Ann C T M Vossen, Janette Rahamat-Langendoen, Willem J G Melchers, Marion P G Koopmans, Annemiek A. van der Eijk, Suzan D. Pas, Anne Marte Bakken Kran, Karoline Bragstad, Susanne Gjeruldsen Dudman, Andreas Christensen, Sidsel Krokstad, Katarzyna Pancer, Edyta Abramczuk, Raquel Guiomar, Pedro Pechirra, Paula Cristovão, Ines Costa, Cristina Tecu, Emilia Lupulescu, Carmen Cherciu, Emily Goldstein, Susan Bennett, Amanda Bradley-Stewart, Rory Gunson, Natasa Berginc, Katarina Prosenc, Magda Campins, Laura Gimferrer, Andres Anton, F. Xavier López-Labrador, Laura Cano Pérez, Joan Puig-Barberá, Concepción Gimeno Cardona, M. Dolores Ocete Mochón, Javier Buesa, David Navarro, R. Ortiz de Lejarazu Leonardo, Iván Sanz Muñoz, Silvia Rojo, Mónica Gozalo-Margüello, Jesús Agüero Balbín, Jan Albert, Agneta Samuelson, Maria Rotzén östlund, Robert Dyrdak, Mia Brytting, Elenor Hauzenberger, Katherina Zakikhany, Margareta Eriksson, Catherine Moore, Eeva Broberg, Pasi Penttinen, Elaine McCulloch, Caterina Di Lorenzo, Paul Wallace, Anton Van Loon, Christiane Prifert, Benedikt Weißbrich, Ortwin Adams, Labor Berlin, Jörg Hofmann, Paus Schnitzler

Research output: Contribution to journalArticle

Abstract

Background: In August and September 2014, unexpected clusters of enterovirus-D68 (EV-D68) infections associated with severe respiratory disease emerged from North-America. In September, the European Centre for Disease Prevention and Control (ECDC) asked European countries to strengthen respiratory sample screening for enterovirus detection and typing in cases with severe respiratory presentations. Objectives: To provide a detailed picture of EV-D68 epidemiology in Europe by conducting a retrospective and prospective laboratory analysis of clinical specimens. Study design: An initiative supported by the European Society for Clinical Virology (ESCV) and ECDC was launched to screen for EV-D68 in respiratory specimens between July 1st and December 1st 2014 in Europe and to sequence the VP1 region of detected viruses for phylogenetic analytic purposes. Results: Forty-two institutes, representing 51 laboratories from 17 European countries, analyzed 17,248 specimens yielding 389 EV-D68 positive samples (2.26%) in 14 countries. The proportion of positive samples ranged between 0 and 25% per country. These infections resulted primarily in mild respiratory disease, mainly detected in young children presenting with wheezing and in immuno-compromised adults. The viruses detected in Europe are genetically very similar to those of the North-American epidemic and the majority (83%) could be assigned to clade B. Except for 3 acute flaccid paralysis (AFP) cases, one death and limited ICU admissions, no severe cases were reported. Conclusions: The European study showed that EV-D68 circulated in Europe during summer and fall of 2014 with a moderate disease burden and different pathogenic profile compared to the North-American epidemic.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Clinical Virology
Volume71
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • Enterovirus D68
  • Molecular epidemiology
  • Respiratory infection
  • VP1 sequencing

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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    Poelman, R., Schuffenecker, I., Van Leer-Buter, C., Josset, L., Niesters, H. G. M., Lina, B., Popow-Kraupp, T., Aberle, S. W., Fischer, T. K., Midgley, S., Christiansen, C. B., Waris, M., österback, R., Vuorinen, T., Savolainen-Kopra, C., Latronico, F., Blomqvist, S., Ikonen, N., Lappalainen, M., ... Schnitzler, P. (2015). European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014. Journal of Clinical Virology, 71, 1-9. https://doi.org/10.1016/j.jcv.2015.07.296