European survey on the use of prophylactic fluconazole in neonatal intensive care units

Florentia Kaguelidou, Chiara Pandolfini, Paolo Manzoni, Imti Choonara, Maurizio Bonati, Evelyne Jacqz-Aigrain

Research output: Contribution to journalArticlepeer-review


Neonatal fungal infections are associated with substantial mortality and morbidity. Although prophylactic use of several antifungals has been proposed, this practice remains controversial. In order to evaluate the use of fluconazole prophylaxis in European NICUs, we conducted a cross-sectional survey by means of a structured questionnaire that was sent to European level II and III neonatal intensive care units, over a 9-month period, as part of a neonatal research FP7 European project. A total of 193 questionnaires from 28 countries were analysed. Use of antifungal prophylaxis was reported by 55% of the responders, and the most frequently used antifungal agent was fluconazole (92%). Main indications for prophylaxis were low gestational age (

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalEuropean Journal of Pediatrics
Issue number3
Publication statusPublished - Mar 2012


  • Fluconazole
  • Intensive care
  • Neonatology
  • Prophylaxis
  • Survey

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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