European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Emrah Düzel, Julio Acosta-Cabronero, David Berron, Geert Jan Biessels, Isabella Björkman-Burtscher, Michel Bottlaender, Richard Bowtell, Mark v. Buchem, Arturo Cardenas-Blanco, Fawzi Boumezbeur, Dennis Chan, Stuart Clare, Mauro Costagli, Ludovic de Rochefort, Ariane Fillmer, Penny Gowland, Oskar Hansson, Jeroen Hendrikse, Oliver Kraff, Mark E. LaddItamar Ronen, Esben Petersen, James B. Rowe, Hartwig Siebner, Tony Stoecker, Sina Straub, Michela Tosetti, Kamil Uludag, Alexandre Vignaud, Jaco Zwanenburg, Oliver Speck

Research output: Contribution to journalArticle

Abstract

Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.

Original languageEnglish
Pages (from-to)538-549
Number of pages12
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume11
DOIs
Publication statusPublished - Dec 2019

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Keywords

  • Alzheimer's disease (AD)
  • Magnetic resonance imaging (MRI)
  • Mild cognitive impairment (MCI)
  • Parkinson's disease (PD)
  • Subjective cognitive decline (SCD)
  • Ultrahigh-field MRI
  • Vascular dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Düzel, E., Acosta-Cabronero, J., Berron, D., Biessels, G. J., Björkman-Burtscher, I., Bottlaender, M., Bowtell, R., Buchem, M. V., Cardenas-Blanco, A., Boumezbeur, F., Chan, D., Clare, S., Costagli, M., de Rochefort, L., Fillmer, A., Gowland, P., Hansson, O., Hendrikse, J., Kraff, O., ... Speck, O. (2019). European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND). Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 11, 538-549. https://doi.org/10.1016/j.dadm.2019.04.010