Europium-154 contamination levels in Samarium-153-EDTMP for radionuclide therapy

L. Moro, D. Fantinato, F. Frigerio, G. Shamhan, G. Angelovski

Research output: Contribution to journalArticle

Abstract

153Sm-EDTMP, a useful non toxic bone seeking isotope in the palliative radionuclide therapy for bone metastases, is produced by neutron activation of enriched of 152Sm 2O 3 targets. During the large-scale formation of 153Sm, however, there is a co-production of some long-lived radio nuclides, among which 154Eu is a major and inevitable radionuclide impurity. The level of 154Eu contamination was evaluated performing a gamma-ray spectrometry of a radiopharmaceutical sample and the urine of an administered patient. As expected, gamma-ray spectra revealed the presence of 153Eu in all the samples. The specific activity of 153Eu in the urine sample collected at 6 hours after injection is 21 Bq/ml and is less than 1 Bq/ml in 24 hr. The contamination levels of 153Eu, normalized to the corresponding activity of 153Sm, were 0.0012% in the residual and in the first urine sample and 0.0017% and 0.0031% at 30 and 54 hours after administration, respectively. The results of this study show that the level of the long-lived 153Eu impurity is not a limitation in the metastatic bone pain palliation due to the additional radiation dose burden, but could pose a cause of concern in case of discharging.

Original languageEnglish
Article number063
Pages (from-to)535-537
Number of pages3
JournalJournal of Physics: Conference Series
Volume41
Issue number1
DOIs
Publication statusPublished - May 1 2006

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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