EUS-guided tissue sampling with a 20-gauge core biopsy needle for the characterization of gastrointestinal subepithelial lesions: A multicenter study

Filippo Antonini, Gabriele Delconte, Lorenzo Fuccio, Germana De Nucci, Carlo Fabbri, Elia Armellini, Leonardo Frazzoni, Adele Fornelli, Andrea Magarotto, Enzo Mandelli, Pietro Occhipinti, Enzo Masci, Gianpiero Manes, Giampiero Macarri

Research output: Contribution to journalArticle

Abstract

Background and Objective: A new 20-gauge (G) biopsy needle with a core-trap technology has been developed with a large core size and enhanced flexibility. The aim of this multicenter study was to determine the feasibility, efficacy, and safety of EUS-guided fine-needle biopsy (EUS-FNB) with the new 20G needle in diagnosing subepithelial lesions (SELs). Materials and Methods: Retrospectively collected data from consecutive patients with SELs undergoing EUS-FNB with the 20G needle at five centers were analyzed. Results: A total of 50 SELs were included. The mean lesion size was 43.1 ± 17.5 mm. The lesion locations were esophagus (n = 1), stomach (n = 37), distal duodenum (n = 5), rectum (n = 6), and colon (n = 1). The procedure was technically feasible in all patients. Definitive diagnosis with full histological assessment including immunohistochemistry was obtained in 88% (44/50) of the patients. Considering malignant versus benign lesions, the sensitivity, specificity, positive predictive value, and negative predictive value were 85% (95% confidence interval [CI] 70.2-94.3), 100% (95% CI 58.7%-100%), 100% (95% CI 85.1%-100%), and 62.5 (95% CI 27.7-84.8), respectively. No major complications requiring additional care have been observed. Conclusions: In this multicenter study, we found that EUS-FNB with the new 20G core needle is an effective and safe method for the diagnosis of SELs with a high rate of producing adequate histological material and high diagnostic accuracy even from difficult-to-approach anatomical locations.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalEndoscopic Ultrasound
Volume8
Issue number2
DOIs
Publication statusPublished - Mar 1 2019

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Large-Core Needle Biopsy
Multicenter Studies
Fine Needle Biopsy
Confidence Intervals
Needles
Needle Biopsy
Duodenum
Rectum
Esophagus
Stomach
Colon
Immunohistochemistry
Technology
Safety
Sensitivity and Specificity

Keywords

  • Endoscopic ultrasound
  • fine-needle aspiration
  • gastrointestinal stromal tumor
  • subepithelial lesion
  • submucosal mass

ASJC Scopus subject areas

  • Hepatology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

EUS-guided tissue sampling with a 20-gauge core biopsy needle for the characterization of gastrointestinal subepithelial lesions : A multicenter study. / Antonini, Filippo; Delconte, Gabriele; Fuccio, Lorenzo; De Nucci, Germana; Fabbri, Carlo; Armellini, Elia; Frazzoni, Leonardo; Fornelli, Adele; Magarotto, Andrea; Mandelli, Enzo; Occhipinti, Pietro; Masci, Enzo; Manes, Gianpiero; Macarri, Giampiero.

In: Endoscopic Ultrasound, Vol. 8, No. 2, 01.03.2019, p. 105-110.

Research output: Contribution to journalArticle

Antonini, F, Delconte, G, Fuccio, L, De Nucci, G, Fabbri, C, Armellini, E, Frazzoni, L, Fornelli, A, Magarotto, A, Mandelli, E, Occhipinti, P, Masci, E, Manes, G & Macarri, G 2019, 'EUS-guided tissue sampling with a 20-gauge core biopsy needle for the characterization of gastrointestinal subepithelial lesions: A multicenter study', Endoscopic Ultrasound, vol. 8, no. 2, pp. 105-110. https://doi.org/10.4103/eus.eus-1-18
Antonini, Filippo ; Delconte, Gabriele ; Fuccio, Lorenzo ; De Nucci, Germana ; Fabbri, Carlo ; Armellini, Elia ; Frazzoni, Leonardo ; Fornelli, Adele ; Magarotto, Andrea ; Mandelli, Enzo ; Occhipinti, Pietro ; Masci, Enzo ; Manes, Gianpiero ; Macarri, Giampiero. / EUS-guided tissue sampling with a 20-gauge core biopsy needle for the characterization of gastrointestinal subepithelial lesions : A multicenter study. In: Endoscopic Ultrasound. 2019 ; Vol. 8, No. 2. pp. 105-110.
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abstract = "Background and Objective: A new 20-gauge (G) biopsy needle with a core-trap technology has been developed with a large core size and enhanced flexibility. The aim of this multicenter study was to determine the feasibility, efficacy, and safety of EUS-guided fine-needle biopsy (EUS-FNB) with the new 20G needle in diagnosing subepithelial lesions (SELs). Materials and Methods: Retrospectively collected data from consecutive patients with SELs undergoing EUS-FNB with the 20G needle at five centers were analyzed. Results: A total of 50 SELs were included. The mean lesion size was 43.1 ± 17.5 mm. The lesion locations were esophagus (n = 1), stomach (n = 37), distal duodenum (n = 5), rectum (n = 6), and colon (n = 1). The procedure was technically feasible in all patients. Definitive diagnosis with full histological assessment including immunohistochemistry was obtained in 88{\%} (44/50) of the patients. Considering malignant versus benign lesions, the sensitivity, specificity, positive predictive value, and negative predictive value were 85{\%} (95{\%} confidence interval [CI] 70.2-94.3), 100{\%} (95{\%} CI 58.7{\%}-100{\%}), 100{\%} (95{\%} CI 85.1{\%}-100{\%}), and 62.5 (95{\%} CI 27.7-84.8), respectively. No major complications requiring additional care have been observed. Conclusions: In this multicenter study, we found that EUS-FNB with the new 20G core needle is an effective and safe method for the diagnosis of SELs with a high rate of producing adequate histological material and high diagnostic accuracy even from difficult-to-approach anatomical locations.",
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AU - Antonini, Filippo

AU - Delconte, Gabriele

AU - Fuccio, Lorenzo

AU - De Nucci, Germana

AU - Fabbri, Carlo

AU - Armellini, Elia

AU - Frazzoni, Leonardo

AU - Fornelli, Adele

AU - Magarotto, Andrea

AU - Mandelli, Enzo

AU - Occhipinti, Pietro

AU - Masci, Enzo

AU - Manes, Gianpiero

AU - Macarri, Giampiero

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N2 - Background and Objective: A new 20-gauge (G) biopsy needle with a core-trap technology has been developed with a large core size and enhanced flexibility. The aim of this multicenter study was to determine the feasibility, efficacy, and safety of EUS-guided fine-needle biopsy (EUS-FNB) with the new 20G needle in diagnosing subepithelial lesions (SELs). Materials and Methods: Retrospectively collected data from consecutive patients with SELs undergoing EUS-FNB with the 20G needle at five centers were analyzed. Results: A total of 50 SELs were included. The mean lesion size was 43.1 ± 17.5 mm. The lesion locations were esophagus (n = 1), stomach (n = 37), distal duodenum (n = 5), rectum (n = 6), and colon (n = 1). The procedure was technically feasible in all patients. Definitive diagnosis with full histological assessment including immunohistochemistry was obtained in 88% (44/50) of the patients. Considering malignant versus benign lesions, the sensitivity, specificity, positive predictive value, and negative predictive value were 85% (95% confidence interval [CI] 70.2-94.3), 100% (95% CI 58.7%-100%), 100% (95% CI 85.1%-100%), and 62.5 (95% CI 27.7-84.8), respectively. No major complications requiring additional care have been observed. Conclusions: In this multicenter study, we found that EUS-FNB with the new 20G core needle is an effective and safe method for the diagnosis of SELs with a high rate of producing adequate histological material and high diagnostic accuracy even from difficult-to-approach anatomical locations.

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