Evaluating antirheumatic treatments using synovial biopsy: A recommendation for standardisation to be used in clinical trials

Marleen G H Van De Sande, Danielle M. Gerlag, Beatrijs M. Lodde, Lisa G M Van Baarsen, Stefano Alivernini, Veronica Codullo, Ioana Felea, Elsa Vieira-Sousa, Ursula Fearon, Richard Reece, Carlomaurizio Montecucco, Douglas J. Veale, Costantino Pitzalis, Paul Emery, Lars Klareskog, Iain B. McInnes, Paul P. Tak

Research output: Contribution to journalArticle

Abstract

Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number3
DOIs
Publication statusPublished - Mar 2011

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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    Van De Sande, M. G. H., Gerlag, D. M., Lodde, B. M., Van Baarsen, L. G. M., Alivernini, S., Codullo, V., Felea, I., Vieira-Sousa, E., Fearon, U., Reece, R., Montecucco, C., Veale, D. J., Pitzalis, C., Emery, P., Klareskog, L., McInnes, I. B., & Tak, P. P. (2011). Evaluating antirheumatic treatments using synovial biopsy: A recommendation for standardisation to be used in clinical trials. Annals of the Rheumatic Diseases, 70(3), 423-427. https://doi.org/10.1136/ard.2010.139550