Evaluating prognostic utility of preoperative Neutrophil to Lymphocyte Ratio and hsa-let-7g/c up-regulation in patients with urinary bladder cancer

Nouha Setti Boubaker, Aymone Gurtner, Nesrine Trabelsi, Isabella Manni, Rahma Said, Haroun Ayed, Meriem Ksentini, Omar Karray, Ahmed Saadi, Mohamed Ali Essid, Ahlem Blel, Soumaya Rammeh, Mohamed Chebil, Giulia Piaggio, Slah Ouerhani

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Stratification and risk-evaluation of bladder cancer (BCa) patients are far-reached issues, especially for those with non muscle invasive disease. Thus, setting-up biomarkers, especially after resection of the primary tumor, is crucial. Specifically, Neutrophil to lymphocyte ratio NLR and let-7 deregulation which have been preliminarily but not consistently described to be associated to unfavorable prognosis. OBJECTIVE: To explore the clinical value of pre-treatment Neutrophil to Lymphocyte Ratio (NLR), let-7c and let-7g's deregulation. METHODS: Data were extracted from ninety BCa samples. Pre-treatment NLR was estimated as the absolute neutrophil count divided by the absolute lymphocyte count. Expression patterns of let-7c and let-7g were assessed by qRT-PCR. Correlation with clinical characteristics was performed by descriptive statistics. RESULTS: Both let-7 miRs were upregulated. Interestingly, let-7g was associated to pathological stage (p= 0.001) and tumor multiplicity (p= 0.003). NLR was associated to histological grade (p= 0.005) and clinical stage (p= 0.006). They were both associated to more aggressive phenotype and their worth as potential stratification biomarkers was confirmed by ROC curve. CONCLUSIONS: Our data demonstrated the potential clinical value of all markers, especially pretreatment NLR and let-7g. Further studies are recommended to confirm their utility in improving the clinical decision-making regarding treatment and follow-up scheduling.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalCancer biomarkers : section A of Disease markers
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • biomarkers
  • let-7
  • neoplasms
  • NLR
  • stratification
  • Urinary bladder

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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