Evaluating Sex and Age Differences in ADI-R and ADOS Scores in a Large European Multi-site Sample of Individuals with Autism Spectrum Disorder

J. Tillmann, K. Ashwood, M. Absoud, S. Bölte, F. Bonnet-Brilhault, J. K. Buitelaar, S. Calderoni, R. Calvo, R. Canal-Bedia, R. Canitano, A. De Bildt, M. Gomot, P. J. Hoekstra, A. Kaale, H. McConachie, D. G. Murphy, A. Narzisi, I. Oosterling, M. Pejovic-Milovancevic, A. M. PersicoO. Puig, H. Roeyers, N. Rommelse, R. Sacco, V. Scandurra, A. C. Stanfield, E. Zander, T. Charman

Research output: Contribution to journalArticle

Abstract

Research on sex-related differences in Autism Spectrum Disorder (ASD) has been impeded by small samples. We pooled 28 datasets from 18 sites across nine European countries to examine sex differences in the ASD phenotype on the ADI-R (376 females, 1763 males) and ADOS (233 females, 1187 males). On the ADI-R, early childhood restricted and repetitive behaviours were lower in females than males, alongside comparable levels of social interaction and communication difficulties in females and males. Current ADI-R and ADOS scores showed no sex differences for ASD severity. There were lower socio-communicative symptoms in older compared to younger individuals. This large European ASD sample adds to the literature on sex and age variations of ASD symptomatology.

Original languageEnglish
Pages (from-to)2490-2505
Number of pages16
JournalJournal of Autism and Developmental Disorders
Volume48
Issue number7
DOIs
Publication statusPublished - Jul 1 2018

Keywords

  • Age
  • Autism Spectrum Disorder
  • Phenotype
  • Sex
  • Symptom severity

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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