TY - JOUR
T1 - Evaluating the benefits of an antihypertensive agent using trials based on event and organ damage
T2 - The systolic hypertension in the elderly long-term lacidipine (SHELL) trial and the european lacidipine study on atherosclerosis (ELSA)
AU - Zanchetti, Alberto
PY - 1995
Y1 - 1995
N2 - Aims: To assess the benefits of the calcium antagonist lacidipine on the prevention of cardiovascular events and the prevention of organ damage in two long-term clinical trials. Systolic hypertension in the elderly lone-term lacidipine (SHELL) trial: In the SHELL trial, the efficacy of lacidipine-based treatment is to be compared with that of thiazide-like diuretic (chlorthalidone)-based treatment in elderly patients with isolated systolic hypertension. The incidence of cardiovascular mortality and cardiovascular morbidity over a 5-year period are endpoints. European lacidipine study on atherosclerosis (ELSA) trial: In the ELSA trial, the effects of lacidipine-based treatment and β-blocker (atenolol)-based treatment on the development and progression of carotid atherosclerosis are to be assessed in hypertensive patients. The primary endpoint of this study is the rate of change in the thickness of the carotid artery wall, measured with B-mode ultrasound.
AB - Aims: To assess the benefits of the calcium antagonist lacidipine on the prevention of cardiovascular events and the prevention of organ damage in two long-term clinical trials. Systolic hypertension in the elderly lone-term lacidipine (SHELL) trial: In the SHELL trial, the efficacy of lacidipine-based treatment is to be compared with that of thiazide-like diuretic (chlorthalidone)-based treatment in elderly patients with isolated systolic hypertension. The incidence of cardiovascular mortality and cardiovascular morbidity over a 5-year period are endpoints. European lacidipine study on atherosclerosis (ELSA) trial: In the ELSA trial, the effects of lacidipine-based treatment and β-blocker (atenolol)-based treatment on the development and progression of carotid atherosclerosis are to be assessed in hypertensive patients. The primary endpoint of this study is the rate of change in the thickness of the carotid artery wall, measured with B-mode ultrasound.
KW - Antihypertensive treatment
KW - Atherosclerosis
KW - Cardiovascular events
KW - Carotid intima-media thickness
KW - Lacidipine
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M3 - Article
C2 - 8824685
AN - SCOPUS:0029584472
VL - 13
SP - S35-S39
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
ER -