Evaluating the role of the genetic variations of PTPN22, NFkB1 and FcGRIIIA genes in inflammatory bowel disease: A meta-analysis

Anna Latiano, Orazio Palmieri, Maria Rosa Valvano, Fabrizio Bossa, Tiziana Latiano, Giuseppe Corritore, Ermelinda DeSanto, Angelo Andriulli, Vito Annese

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We tested several polymorphisms of genes involved in the mucosal immune system in a population of inflammatory bowel disease (IBD) patients to investigate their possible implication in disease predisposition. Methods: Polymorphisms of 3 candidate genes (PTPN22, NFkB1, and FcGRIIIA) were investigated in 649 IBD patients (343 with Crohn's disease [CD] and 306 with ulcerative colitis [UC]), 176 unaffected relatives, and 256 healthy controls. Allele and genotype frequencies were correlated with clinical characteristics and major variants of the CARD 15 gene. Our findings were pooled in a meta-analysis with the available studies in the literature. Results: No significant difference for the PTPN22 and NFkB1 variants was found. In contrast, allele and genotype frequencies of the G559T allele of the FcGRIIIA gene were significantly different in CD patients compared to controls (allele T 12% versus 8%, odds ratio [OR] = 1.58, 95% confidence interval [CI] 1.06-2.35; GT genotype 23% versus 16%, OR = 1.64, 95% CI = 1.08-2.5). However, no significant overtransmission of the T allele was confirmed at the family-based analysis. For all genes, neither an interaction with CARD15 gene, nor a significant difference at genotype/phenotype analysis was demonstrated, included response to medical therapy. Conclusions: Although involved in autoimmune diseases, the PTPN22 and NFkB1 genes do not seem involved in the IBD predisposition, also according to meta-analysis results. The association with the G559T polymorphism of the FcGRIIIA gene in CD patients deserves further investigation.

Original languageEnglish
Pages (from-to)1212-1219
Number of pages8
JournalInflammatory Bowel Diseases
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 2007

Keywords

  • CARD15
  • Crohn's disease
  • FcGRIIIA
  • Genotype/phenotype
  • Inflammatory bowel disease
  • NFkB1
  • PTPN22
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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