Evaluation of a new collagen-based medical device (ElastiCo®) for the treatment of acute Achilles tendon injury and prevention of peritendinous adhesions: an in vitro biocompatibility and in vivo investigation

Francesca Veronesi, Gianluca Giavaresi, Davide Bellini, Veronica Casagranda, Daniele Pressato, Milena Fini

Research output: Contribution to journalArticlepeer-review

Abstract

Tendon healing still represents a challenge for clinicians because it is slow and incomplete. The most injured is the Achilles tendon and surgery is the therapeutic strategy often adopted because it provides a quicker functional recovery. Peritendinous adhesions are the main complication of surgery with hyperplasia and chemotaxis of fibroblasts. A biomaterial that blocks fibroblast migration, without interfering with the passage of cytokines and growth factors, might be useful. The present study evaluated the biocompatibility of a new Type I collagen-based scaffold (ElastiCo®) and its ability to promote Achilles tendon healing, inhibiting adhesion formation. After verifying in vitro biocompatibility, physical and mechanical properties of the scaffold, an in vivo study was performed in 28 rats, operated to induce an acute lesion in both Achilles tendons. One tendon was treated with the suture only and the controlateral one with suture wrapped with ElastiCo® film. After 8 and 16 weeks, it was observed that ElastiCo® reduced internal and external peritendinous adhesions and Collagen III content and increased Collagen I. Elastic modulus increased with both treatments over time. Current results highlighted the clinical translationality of ElastiCo® that could improve the quality of life in patients affected by Achilles tendon lesions surgically treated.

Original languageEnglish
Pages (from-to)1113-1125
Number of pages13
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume14
Issue number8
Early online dateJul 27 2020
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Achilles tendon
  • suture
  • peritendinous adhesions
  • collagen
  • in vivo study
  • rats

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