Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy

Marco Ardigò, Caterina Longo, Antonio Cristaudo, Enzo Berardesca, Giovanni Pellacani

Research output: Contribution to journalArticlepeer-review


Background: Confocal microscopy has been successfully applied both in oncologic and inflammatory diseases. In particular, it has been proved as a useful tool for the in vivo detection of microscopical changes occurring in allergic reactions. Aims of the study: To evaluate microscopic changes occurring in positive patch test reactions. Methods: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy. Results: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in the middle of the spongiotic phenomena. Conclusion: Confocal microscopy offered for the first time new insight into vesicle formation and development, showing that adnexal ducts can play a role in allergic reaction.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalSkin Research and Technology
Issue number1
Publication statusPublished - Feb 2012


  • Adnexal structures
  • Allergic vesicular reaction
  • Confocal microscopy

ASJC Scopus subject areas

  • Dermatology

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