Evaluation of antibiotic-induced nephrotoxicity in preterm neonates by determining urinary α1-microglobulin

Vassilios Fanos, Michele Mussap, Giuseppe Verlato, Mario Plebani, Ezio Maria Padovani

Research output: Contribution to journalArticlepeer-review


α1-Microglobulin (α1-m, protein HC), a relatively low molecular weight protein of about 31,000 daltons, was measured in urine of three groups of 34 preterm neonates: group A consisted of 9 healthy preterm neonates; groups B (n = 13) and C (n = 12) consisted of preterm neonates with suspected or confirmed bacterial infections. Immediately after birth, all group B neonates were treated with ampicillin and aztreonam in combination, and all group C neonates were treated with oxacillin and amikacin in combination. To optimize amikacin administration, computerized individually tailored doses were administered. Urine samples were obtained from a short collection in sterile bags on the 1st, 4th, and 7th day after delivery in all infants. Urinary α1-m concentrations were measured by a turbidimetric method (latex agglutination photometric immunoassay) and results were expressed as a ratio to urinary creatinine. In group A, urinary α1-m concentrations were stable after birth. In group C, α1-m excretion increased immediately within the 1st day of treatment, and over the 1st week of life urinary α1-m levels were significantly higher than in group A (P = 0.033). These data support the conclusion that amikacin administration was the most important factor inducing renal tubular dysfunction in the neonates of group C.

Original languageEnglish
Pages (from-to)645-647
Number of pages3
JournalPediatric Nephrology
Issue number5
Publication statusPublished - 1996


  • α-Microglobulin
  • Antibiotics
  • Nephrotoxicity neonates

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health


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