TY - JOUR
T1 - Evaluation of antibiotic-induced nephrotoxicity in preterm neonates by determining urinary α1-microglobulin
AU - Fanos, Vassilios
AU - Mussap, Michele
AU - Verlato, Giuseppe
AU - Plebani, Mario
AU - Padovani, Ezio Maria
PY - 1996
Y1 - 1996
N2 - α1-Microglobulin (α1-m, protein HC), a relatively low molecular weight protein of about 31,000 daltons, was measured in urine of three groups of 34 preterm neonates: group A consisted of 9 healthy preterm neonates; groups B (n = 13) and C (n = 12) consisted of preterm neonates with suspected or confirmed bacterial infections. Immediately after birth, all group B neonates were treated with ampicillin and aztreonam in combination, and all group C neonates were treated with oxacillin and amikacin in combination. To optimize amikacin administration, computerized individually tailored doses were administered. Urine samples were obtained from a short collection in sterile bags on the 1st, 4th, and 7th day after delivery in all infants. Urinary α1-m concentrations were measured by a turbidimetric method (latex agglutination photometric immunoassay) and results were expressed as a ratio to urinary creatinine. In group A, urinary α1-m concentrations were stable after birth. In group C, α1-m excretion increased immediately within the 1st day of treatment, and over the 1st week of life urinary α1-m levels were significantly higher than in group A (P = 0.033). These data support the conclusion that amikacin administration was the most important factor inducing renal tubular dysfunction in the neonates of group C.
AB - α1-Microglobulin (α1-m, protein HC), a relatively low molecular weight protein of about 31,000 daltons, was measured in urine of three groups of 34 preterm neonates: group A consisted of 9 healthy preterm neonates; groups B (n = 13) and C (n = 12) consisted of preterm neonates with suspected or confirmed bacterial infections. Immediately after birth, all group B neonates were treated with ampicillin and aztreonam in combination, and all group C neonates were treated with oxacillin and amikacin in combination. To optimize amikacin administration, computerized individually tailored doses were administered. Urine samples were obtained from a short collection in sterile bags on the 1st, 4th, and 7th day after delivery in all infants. Urinary α1-m concentrations were measured by a turbidimetric method (latex agglutination photometric immunoassay) and results were expressed as a ratio to urinary creatinine. In group A, urinary α1-m concentrations were stable after birth. In group C, α1-m excretion increased immediately within the 1st day of treatment, and over the 1st week of life urinary α1-m levels were significantly higher than in group A (P = 0.033). These data support the conclusion that amikacin administration was the most important factor inducing renal tubular dysfunction in the neonates of group C.
KW - α-Microglobulin
KW - Antibiotics
KW - Nephrotoxicity neonates
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U2 - 10.1007/s004670050181
DO - 10.1007/s004670050181
M3 - Article
C2 - 8897576
AN - SCOPUS:0029778998
VL - 10
SP - 645
EP - 647
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 5
ER -