Evaluation of antisecretory activity of misoprostol in duodenal ulcer patients using long-term intragastric pH monitoring

V. Savarino, P. Scalabrini, G. S. Mela, E. Di Timoteo, G. Percario, M. R. Magnolia, G. Celle

Research output: Contribution to journalArticle

Abstract

The effect of the new synthetic prostaglandin E1analog, misoprostol, on intragastric acidity was evaluated by means of 24-hr intraluminal pH monitoring of 16 duodenal ulcer patients. They were randomly allocated into two groups: eight received no medication and misoprostol 400 Μg bid and eight received ranitidine 150 mg and misoprostol 400 Μg bid not less than one week apart. The comparison of the 24-hr areas under the curve related to the median pH values showed that no difference existed between misoprostol and untreated patients in the first group, while ranitidine was significantly more effective (P= 0.00003) than misoprostol in the second group. The analysis of arithmetic differences between the 24-hr median pH values showed that misoprostol increased pH values by at least one unit compared to the untreated subgroup for about 3.5 hr, while the antisecretory action of ranitidine was far superior to that of misoprostol throughout the whole 24-hr period. It can be concluded that the effect of twice daily doses of misoprostol 400 Μg on 24-hr intragastric pH is small and not at all comparable to that of the well-known potent H2blocker ranitidine.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalDigestive Diseases and Sciences
Volume33
Issue number3
DOIs
Publication statusPublished - Mar 1988

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Keywords

  • intragastric acidity
  • misoprostol
  • pH monitoring
  • ranitidine

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Savarino, V., Scalabrini, P., Mela, G. S., Di Timoteo, E., Percario, G., Magnolia, M. R., & Celle, G. (1988). Evaluation of antisecretory activity of misoprostol in duodenal ulcer patients using long-term intragastric pH monitoring. Digestive Diseases and Sciences, 33(3), 293-297. https://doi.org/10.1007/BF01535752