Evaluation of atherosclerotic lesions using NMR microimaging

M. Asdente, L. Pavesi, P. L. Oreste, A. Colombo, W. Kuhn, E. Tremoli

Research output: Contribution to journalArticle

Abstract

Magnetic resonance imaging (MRI) has been proposed as a potential tool in the evaluation of atherosclerotic lesions. However, two basic difficulties have to date prevented the full exploitation of the potentials of this technique: the poor spatial resolution of the conventional tomographs and the wide variety of the lesions as well as their intrinsic dishomogeneity. In this study the in vitro morphology of normal and atherosclerotic vascular tissue specimens has been evaluated using a high resolution spectometer equipped with a microimaging device. Morphological features of the vessel walls as small as 10-1 mm have been detected and the distribution of lipids and of calcified or necrotic regions has been evidenced in atherosclerotic plaques. Different techniques, such as local spectroscopy performed on volumes of 1 mm3 and localized magnetization recovery measurements, have been employed to characterize specific regions of the vessel walls from the chemical and the physical point of view. The good agreement of NMR findings with histological data allows us to conclude that NMR microimaging represents a suitable technique for the in vitro detection and characterization of atheromatous lesions.

Original languageEnglish
Pages (from-to)243-253
Number of pages11
JournalAtherosclerosis
Volume80
Issue number3
DOIs
Publication statusPublished - 1990

Keywords

  • Atherosclerosis
  • NMR chemical shift images
  • NMR microimaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Evaluation of atherosclerotic lesions using NMR microimaging'. Together they form a unique fingerprint.

  • Cite this

    Asdente, M., Pavesi, L., Oreste, P. L., Colombo, A., Kuhn, W., & Tremoli, E. (1990). Evaluation of atherosclerotic lesions using NMR microimaging. Atherosclerosis, 80(3), 243-253. https://doi.org/10.1016/0021-9150(90)90032-E