Valutazione delle modificazioni emodinamiche a livello dei gangli della base mediante risonanza magnetica perfusionale nel soggetti affetti da morbo di Parkinson

Translated title of the contribution: Evaluation of basal ganglia haemodynamic changes with perfusion-weighted magnetic resonance imaging in patients with Parkinson's disease

F. Gaudiello, F. G. Garaci, S. Marziali, A. Ludovici, L. Brusa, P. Stanzione, R. Floris, G. Simonetti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. The aim of our study was to assess the regional cerebral blood flow (rCBF) of basal ganglia and thalami in patients with Parkinson's disease (PD) using perfusion-weighted magnetic resonance imaging (PW-MRI). Material and methods. Twenty subjects affected by idiopathic PD according to the United Kingdom Brain Bank criteria were enrolled in the study. Twenty normal subjects matched for age and gender were included as controls. After 20-day therapy withdrawal, the PD patients underwent PW-MRI. The rCBF was calculated both in patients and in controls. The regions of interest were manually positioned on rCBF maps over the caudate nucleus, the putamen, the external and internal globus pallidus, and over the ventrolateral nucleus of the thalamus. Data were normalised with those obtained from parieto-occipital white matter (POWM). Statistical analysis was performed using a parametric ANOVA test. Results. Patients showed a significant (p

Translated title of the contributionEvaluation of basal ganglia haemodynamic changes with perfusion-weighted magnetic resonance imaging in patients with Parkinson's disease
Original languageItalian
Pages (from-to)284-290
Number of pages7
JournalRadiologia Medica
Volume111
Issue number2
DOIs
Publication statusPublished - Mar 2006

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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