Evaluation of Biomarkers for the Prediction of Venous Thromboembolism in Ambulatory Cancer Patients

Ruth Maria Schorling, Christian Pfrepper, Thomas Golombek, Chiara Alessandra Cella, Nerea Muñoz-Unceta, Roland Siegemund, Christoph Engel, Sirak Petros, Florian Lordick, Maren Knödler

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Venous thromboembolism (VTE) is a common complication of cancer. This study aimed to evaluate immature platelet fraction (IPF), mean platelet volume (MPV), P-selectin, D-dimer, and thrombin generation (TG) as predictive biomarkers for VTE and further the improvement of existing risk assessment models (RAMs). Methods: A prospective, observational, exploratory study was conducted on ambulatory cancer patients with indication for systemic chemotherapy. Baseline RAMs included the Khorana-, Vienna Cancer, Thrombosis-, Protecht-, ONKOTEV-, and Catscore. IPF, MPV, P-selectin, D-dimer, and TG were analysed at baseline and 3-month follow-up. Results: We enrolled 100 patients, of whom 89 completed the follow-up. Frequent tumour types were breast (30%), gastric (14%), gynaecological (14%), and colorectal (14%) cancer. Ten of the 89 patients (11.2%) developed VTE. The highest VTE rate was observed in patients with cholangiocarcinoma (3/5; 60%). Baseline D-dimer levels but not IPF, MPV, or P-selectin were associated with the risk of developing VTE (HR 6.9; p = 0.021). None of the RAMs showed statistical significance in predicting VTE. Peak thrombin and endogenous thrombin potential were lower in patients who developed VTE. Biomarker changes between baseline and follow-up were not associated with VTE risk. Conclusions: VTE risk was well predicted by baseline D-dimer levels. Adding D-dimer could improve existing RAMs to better identify patients who may benefit from primary VTE prophylaxis. The VTE risk among patients with cholangiocarcinoma should be further evaluated.

Original languageEnglish
Pages (from-to)414-426
Number of pages13
JournalOncology Research and Treatment
Volume43
Issue number9
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • Biomarkers
  • Cholangiocarcinoma
  • D-dimer
  • Risk assessment models
  • Venous thromboembolism

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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