Evaluation of blocking mechanisms against immunological responses in patients with laryngeal carcinoma

B. Morra, F. Beatrice, M. Bussi, E. Poggio, A. Sartoris, G. P. Cavallo, V. Di Fortunato, M. Vercellino, Giorgio Cortesina

Research output: Contribution to journalArticlepeer-review

Abstract

The specific tumor-induced leukocyte inhibition factor (LIF) production in laryngeal cancer patients has been investigated before and after the removal of adherent cells in order to evaluate the existence of a suppressor activity; 20 patients served as subject. The LIF production, after challenging the lymphocytes with 3MKC1 autologous tumor extracts, was significant in 12 patients and showed a further significant increase after the removal of adherent cells. In 3 patients with no previous significant LIF production, there was a conversion to significance when the adherent cells were removed. The other patients did not show any significant variation. These data seem to suggest the existence of a suppressor activity exerted by adherent cells in laryngeal cancer patients on LIF production.

Original languageEnglish
Pages (from-to)825-828
Number of pages4
JournalLaryngoscope
Volume94
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint

Dive into the research topics of 'Evaluation of blocking mechanisms against immunological responses in patients with laryngeal carcinoma'. Together they form a unique fingerprint.

Cite this