Evaluation of blood flow velocity in the middle cerebral artery during nonpulsatile hypothermic cardiopulmonary bypass

M. Roberto, F. Alamanni, M. Riboldi, M. Agrifoglio, G. Pompilio, S. Dimatteo, A. Parolari, F. Rossi, P. Biglioli

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Purpose of the study: we evaluated the validity and utility of blood flow velocity measurements by transcranial doppler (TCD) ultrasonography as a tool to indirectly measure cerebral perfusion during cardiopulmonary bypass (CPB). Methods: we simultaneously measured the blood flow velocity (V) changes in the middle cerebral artery (MCA) and physiologic variables in 9 patients undergoing cardiac surgery under hypothermic CPB in who pH and PaCo2 were managed with the alpha-stat acid-base strategy. TCD recordings of systolic, diastolic, and mean VMCA, and derived parameters such as pulsatility (PI) and resistance (RI) indexes were recorded from the right MCA. Results: the mean VMCA was significantly (PMCA was directly correlated (pMCA was directly correlated with CPB flow (pMCA / CPB flow), introduced to make the mean VMCA independent from CPB flow, was significantly correlated only with glycemia. Conclusions: The TCD is a easy and non invasive method to monitor cerebral blood flow velocity during hypothermic CPB. The preliminary results of the study demonstrated, at univariate analysis, a correlation between the VMCA and NPT and CPB flow, but at multivariate analysis only a correlation between the VMCA and CPB flow and an inverse relation with the glycemia. The results partially differ from those of the other studies. There is the necessity to continue this study to explain the absence of correlation between the NPT and the VMCA and to study in depth the relationship between the VMCA and glycemia.

Original languageEnglish
Pages (from-to)99
Number of pages1
JournalScandinavian Journal of Thoracic and Cardiovascular Surgery
Issue numberSUPPL. 44
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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