In a group of 91 subjects including 42 asymptomatic, 22 paucisymptomatic and 27 patients affected with AIDS the plasma levels of fatty acid of phospholipids and vitamin E, and erythrocytic glutathion peroxidase activity were evaluated as parameters of the functionality of cell membranes. These levels were normal only in 14 of asymptomatic and in 3 of paucisymptomatic subjects, who did not present seborrheic dermatitis. Two particular conditions were seen in subjects with altered biochemical parameters: the presence of seborrhoeic dermatitis and the treatment with antiretroviral drugs and other toxic drugs specific to the opportunistic pathology. On the basis of the results obtained, the authors hypothesize that the damage of cell membranes increases along with the progression of HIV infection, ie, AIDS > paucisymptomatic > asymptomatic, > controls. Consequently, in order to perform a rational dietetic-pharmacologic treatment, the authors suggest the evaluation of these parameters not only in seropositive subjects, but also in individuals at risk for HIV infection, especially if they are affected with seborrhoeic dermatitis.
|Translated title of the contribution||Evaluation of blood levels of fatty acids of phospholipids, vitamine E and glutathione peroxidase in HIV seropositive subjects, respectively clinically asymptomatic, paucisymptomatic and with AIDS|
|Number of pages||12|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1997|
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