Valutazione dei livelli ematici degli acidi grassi dei fosfolipidi, vitamina E e glutatione perossidasi insoggetti HIV sieropositivi clinicamente asintomatici, paucisintomatici e con AIDS conclamato

Translated title of the contribution: Evaluation of blood levels of fatty acids of phospholipids, vitamine E and glutathione peroxidase in HIV seropositive subjects, respectively clinically asymptomatic, paucisymptomatic and with AIDS

F. Ippolito, S. Passi, P. Puddu, A. Di Carlo, P. Narciso

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In a group of 91 subjects including 42 asymptomatic, 22 paucisymptomatic and 27 patients affected with AIDS the plasma levels of fatty acid of phospholipids and vitamin E, and erythrocytic glutathion peroxidase activity were evaluated as parameters of the functionality of cell membranes. These levels were normal only in 14 of asymptomatic and in 3 of paucisymptomatic subjects, who did not present seborrheic dermatitis. Two particular conditions were seen in subjects with altered biochemical parameters: the presence of seborrhoeic dermatitis and the treatment with antiretroviral drugs and other toxic drugs specific to the opportunistic pathology. On the basis of the results obtained, the authors hypothesize that the damage of cell membranes increases along with the progression of HIV infection, ie, AIDS > paucisymptomatic > asymptomatic, > controls. Consequently, in order to perform a rational dietetic-pharmacologic treatment, the authors suggest the evaluation of these parameters not only in seropositive subjects, but also in individuals at risk for HIV infection, especially if they are affected with seborrhoeic dermatitis.

Original languageItalian
Pages (from-to)239-250
Number of pages12
JournalGiornale Italiano di Dermatologia e Venereologia
Volume132
Issue number4
Publication statusPublished - 1997

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Dermatitis
Glutathione Peroxidase
HIV Infections
Phospholipids
Acquired Immunodeficiency Syndrome
Fatty Acids
Cell Membrane
HIV
Seborrheic Dermatitis
Dietetics
Poisons
Vitamin E
Pharmaceutical Preparations
Pathology
Therapeutics

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Valutazione dei livelli ematici degli acidi grassi dei fosfolipidi, vitamina E e glutatione perossidasi insoggetti HIV sieropositivi clinicamente asintomatici, paucisintomatici e con AIDS conclamato",
abstract = "In a group of 91 subjects including 42 asymptomatic, 22 paucisymptomatic and 27 patients affected with AIDS the plasma levels of fatty acid of phospholipids and vitamin E, and erythrocytic glutathion peroxidase activity were evaluated as parameters of the functionality of cell membranes. These levels were normal only in 14 of asymptomatic and in 3 of paucisymptomatic subjects, who did not present seborrheic dermatitis. Two particular conditions were seen in subjects with altered biochemical parameters: the presence of seborrhoeic dermatitis and the treatment with antiretroviral drugs and other toxic drugs specific to the opportunistic pathology. On the basis of the results obtained, the authors hypothesize that the damage of cell membranes increases along with the progression of HIV infection, ie, AIDS > paucisymptomatic > asymptomatic, > controls. Consequently, in order to perform a rational dietetic-pharmacologic treatment, the authors suggest the evaluation of these parameters not only in seropositive subjects, but also in individuals at risk for HIV infection, especially if they are affected with seborrhoeic dermatitis.",
keywords = "AIDS, glutathione peroxidase, polyunsaturated fatty acid of phospholipids, risk factors, seborrhoeic dermatitis, vitamine E",
author = "F. Ippolito and S. Passi and P. Puddu and {Di Carlo}, A. and P. Narciso",
year = "1997",
language = "Italian",
volume = "132",
pages = "239--250",
journal = "Minerva dermatologica",
issn = "0392-0488",
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AU - Ippolito, F.

AU - Passi, S.

AU - Puddu, P.

AU - Di Carlo, A.

AU - Narciso, P.

PY - 1997

Y1 - 1997

N2 - In a group of 91 subjects including 42 asymptomatic, 22 paucisymptomatic and 27 patients affected with AIDS the plasma levels of fatty acid of phospholipids and vitamin E, and erythrocytic glutathion peroxidase activity were evaluated as parameters of the functionality of cell membranes. These levels were normal only in 14 of asymptomatic and in 3 of paucisymptomatic subjects, who did not present seborrheic dermatitis. Two particular conditions were seen in subjects with altered biochemical parameters: the presence of seborrhoeic dermatitis and the treatment with antiretroviral drugs and other toxic drugs specific to the opportunistic pathology. On the basis of the results obtained, the authors hypothesize that the damage of cell membranes increases along with the progression of HIV infection, ie, AIDS > paucisymptomatic > asymptomatic, > controls. Consequently, in order to perform a rational dietetic-pharmacologic treatment, the authors suggest the evaluation of these parameters not only in seropositive subjects, but also in individuals at risk for HIV infection, especially if they are affected with seborrhoeic dermatitis.

AB - In a group of 91 subjects including 42 asymptomatic, 22 paucisymptomatic and 27 patients affected with AIDS the plasma levels of fatty acid of phospholipids and vitamin E, and erythrocytic glutathion peroxidase activity were evaluated as parameters of the functionality of cell membranes. These levels were normal only in 14 of asymptomatic and in 3 of paucisymptomatic subjects, who did not present seborrheic dermatitis. Two particular conditions were seen in subjects with altered biochemical parameters: the presence of seborrhoeic dermatitis and the treatment with antiretroviral drugs and other toxic drugs specific to the opportunistic pathology. On the basis of the results obtained, the authors hypothesize that the damage of cell membranes increases along with the progression of HIV infection, ie, AIDS > paucisymptomatic > asymptomatic, > controls. Consequently, in order to perform a rational dietetic-pharmacologic treatment, the authors suggest the evaluation of these parameters not only in seropositive subjects, but also in individuals at risk for HIV infection, especially if they are affected with seborrhoeic dermatitis.

KW - AIDS

KW - glutathione peroxidase

KW - polyunsaturated fatty acid of phospholipids

KW - risk factors

KW - seborrhoeic dermatitis

KW - vitamine E

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