Evaluation of body composition as a potential biomarker in spinal muscular atrophy

Giovanni Baranello, Ramona De Amicis, Maria Teresa Arnoldi, Riccardo Zanin, Chiara Mastella, Riccardo Masson, Alessandro Leone, Katia Alberti, Andrea Foppiani, Alberto Battezzati, Simona Bertoli

Research output: Contribution to journalArticle

Abstract

Introduction: We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)-specific motor function assessments. Methods: Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross-sectional study. The protocol included anthropometric measurements, and dual-energy X-ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat-free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII). Results: Eighty-eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII. Discussion: BC shows promise as a potential biomarker for SMA, but further studies are needed.

Original languageEnglish
Pages (from-to)530-534
Number of pages5
JournalMuscle and Nerve
Volume61
Issue number4
DOIs
Publication statusPublished - Apr 1 2020

Keywords

  • body composition
  • fat-free mass
  • Hammersmith Functional Motor Scale―Expanded
  • spinal muscular atrophy
  • The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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