Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography

M. Turiel, S. Muzzupappa, B. Gottardi, C. Crema, P. Sarzi-Puttini, E. Rossi

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Objective: Valvular lesions are frequently present in Primary Antiphospholipid Syndrome (PAPS) patients using transthoracic and/or transesophageal echocardiography. The aim of this study was to describe the prevalence of cardiac abnormalities (valvular thickening and/or regurgitation) or potential embolic sources (spontaneous echocontrast and/or vegetations) in PAPS patients. Methods: Multiplane transesophageal echocardiography was performed consecutively on 40 PAPS patients: 17 of them with thrombocytopenia, 27 with at least one thromboembolic event (stroke, transient ischaemic attack, arterial and/or venous thrombosis, pulmonary embolism) and 14 with recurrent fetal loss. Design: Cardiac involvement (cardiac abnormalities and/or embolic sources) was present in 33/40 (82%) of PAPS patients. According to aCL titer these lesions were revealed in 17/24 (71%) of patients with aCL ≤ 40 GPL-U, while these lesions were present in 100% of patients with aCL > 40 GPL-U. Three patients presented mitral stenosis and 3 non-infective valve masses or vegetations. Embolic sources were found in 4/24 (17%) patients with aCL ≤ 40 GPL-U, while they were observed in 6/16 (37%) of patients with titer of aCL > 40 GPL-U (χ2 = 10.03, P <0.01). Regression analysis showed a positive correlation between mitral valve thickening and aCL antibodies titer (r = 0.5; P <0.001). Conclusions: Valvular lesions are commonly found in PAPS patients. Our data showed a significant correlation among aCL titer, mitral leaflets thickening and thromboembolic events.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalLupus
Volume9
Issue number6
Publication statusPublished - 2000

Fingerprint

Antiphospholipid Syndrome
Transesophageal Echocardiography
Mitral Valve Stenosis
Transient Ischemic Attack
Pulmonary Embolism
Mitral Valve
Venous Thrombosis
Thrombocytopenia
Echocardiography
Stroke
Regression Analysis

Keywords

  • aCL antibodies
  • Embolic sources
  • Primary antiphospholipid syndrome
  • Transesophageal echocardiography

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Turiel, M., Muzzupappa, S., Gottardi, B., Crema, C., Sarzi-Puttini, P., & Rossi, E. (2000). Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography. Lupus, 9(6), 406-412.

Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography. / Turiel, M.; Muzzupappa, S.; Gottardi, B.; Crema, C.; Sarzi-Puttini, P.; Rossi, E.

In: Lupus, Vol. 9, No. 6, 2000, p. 406-412.

Research output: Contribution to journalArticle

Turiel, M, Muzzupappa, S, Gottardi, B, Crema, C, Sarzi-Puttini, P & Rossi, E 2000, 'Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography', Lupus, vol. 9, no. 6, pp. 406-412.
Turiel, M. ; Muzzupappa, S. ; Gottardi, B. ; Crema, C. ; Sarzi-Puttini, P. ; Rossi, E. / Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography. In: Lupus. 2000 ; Vol. 9, No. 6. pp. 406-412.
@article{0c2f1ddbc31a486795ad96b7a963eb3b,
title = "Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography",
abstract = "Objective: Valvular lesions are frequently present in Primary Antiphospholipid Syndrome (PAPS) patients using transthoracic and/or transesophageal echocardiography. The aim of this study was to describe the prevalence of cardiac abnormalities (valvular thickening and/or regurgitation) or potential embolic sources (spontaneous echocontrast and/or vegetations) in PAPS patients. Methods: Multiplane transesophageal echocardiography was performed consecutively on 40 PAPS patients: 17 of them with thrombocytopenia, 27 with at least one thromboembolic event (stroke, transient ischaemic attack, arterial and/or venous thrombosis, pulmonary embolism) and 14 with recurrent fetal loss. Design: Cardiac involvement (cardiac abnormalities and/or embolic sources) was present in 33/40 (82{\%}) of PAPS patients. According to aCL titer these lesions were revealed in 17/24 (71{\%}) of patients with aCL ≤ 40 GPL-U, while these lesions were present in 100{\%} of patients with aCL > 40 GPL-U. Three patients presented mitral stenosis and 3 non-infective valve masses or vegetations. Embolic sources were found in 4/24 (17{\%}) patients with aCL ≤ 40 GPL-U, while they were observed in 6/16 (37{\%}) of patients with titer of aCL > 40 GPL-U (χ2 = 10.03, P <0.01). Regression analysis showed a positive correlation between mitral valve thickening and aCL antibodies titer (r = 0.5; P <0.001). Conclusions: Valvular lesions are commonly found in PAPS patients. Our data showed a significant correlation among aCL titer, mitral leaflets thickening and thromboembolic events.",
keywords = "aCL antibodies, Embolic sources, Primary antiphospholipid syndrome, Transesophageal echocardiography",
author = "M. Turiel and S. Muzzupappa and B. Gottardi and C. Crema and P. Sarzi-Puttini and E. Rossi",
year = "2000",
language = "English",
volume = "9",
pages = "406--412",
journal = "Lupus",
issn = "0961-2033",
publisher = "SAGE Publications Ltd",
number = "6",

}

TY - JOUR

T1 - Evaluation of cardiac abnormalities and embolic sources in primary antiphospholipid syndrome by transesophageal echocardiography

AU - Turiel, M.

AU - Muzzupappa, S.

AU - Gottardi, B.

AU - Crema, C.

AU - Sarzi-Puttini, P.

AU - Rossi, E.

PY - 2000

Y1 - 2000

N2 - Objective: Valvular lesions are frequently present in Primary Antiphospholipid Syndrome (PAPS) patients using transthoracic and/or transesophageal echocardiography. The aim of this study was to describe the prevalence of cardiac abnormalities (valvular thickening and/or regurgitation) or potential embolic sources (spontaneous echocontrast and/or vegetations) in PAPS patients. Methods: Multiplane transesophageal echocardiography was performed consecutively on 40 PAPS patients: 17 of them with thrombocytopenia, 27 with at least one thromboembolic event (stroke, transient ischaemic attack, arterial and/or venous thrombosis, pulmonary embolism) and 14 with recurrent fetal loss. Design: Cardiac involvement (cardiac abnormalities and/or embolic sources) was present in 33/40 (82%) of PAPS patients. According to aCL titer these lesions were revealed in 17/24 (71%) of patients with aCL ≤ 40 GPL-U, while these lesions were present in 100% of patients with aCL > 40 GPL-U. Three patients presented mitral stenosis and 3 non-infective valve masses or vegetations. Embolic sources were found in 4/24 (17%) patients with aCL ≤ 40 GPL-U, while they were observed in 6/16 (37%) of patients with titer of aCL > 40 GPL-U (χ2 = 10.03, P <0.01). Regression analysis showed a positive correlation between mitral valve thickening and aCL antibodies titer (r = 0.5; P <0.001). Conclusions: Valvular lesions are commonly found in PAPS patients. Our data showed a significant correlation among aCL titer, mitral leaflets thickening and thromboembolic events.

AB - Objective: Valvular lesions are frequently present in Primary Antiphospholipid Syndrome (PAPS) patients using transthoracic and/or transesophageal echocardiography. The aim of this study was to describe the prevalence of cardiac abnormalities (valvular thickening and/or regurgitation) or potential embolic sources (spontaneous echocontrast and/or vegetations) in PAPS patients. Methods: Multiplane transesophageal echocardiography was performed consecutively on 40 PAPS patients: 17 of them with thrombocytopenia, 27 with at least one thromboembolic event (stroke, transient ischaemic attack, arterial and/or venous thrombosis, pulmonary embolism) and 14 with recurrent fetal loss. Design: Cardiac involvement (cardiac abnormalities and/or embolic sources) was present in 33/40 (82%) of PAPS patients. According to aCL titer these lesions were revealed in 17/24 (71%) of patients with aCL ≤ 40 GPL-U, while these lesions were present in 100% of patients with aCL > 40 GPL-U. Three patients presented mitral stenosis and 3 non-infective valve masses or vegetations. Embolic sources were found in 4/24 (17%) patients with aCL ≤ 40 GPL-U, while they were observed in 6/16 (37%) of patients with titer of aCL > 40 GPL-U (χ2 = 10.03, P <0.01). Regression analysis showed a positive correlation between mitral valve thickening and aCL antibodies titer (r = 0.5; P <0.001). Conclusions: Valvular lesions are commonly found in PAPS patients. Our data showed a significant correlation among aCL titer, mitral leaflets thickening and thromboembolic events.

KW - aCL antibodies

KW - Embolic sources

KW - Primary antiphospholipid syndrome

KW - Transesophageal echocardiography

UR - http://www.scopus.com/inward/record.url?scp=0033915833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033915833&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 406

EP - 412

JO - Lupus

JF - Lupus

SN - 0961-2033

IS - 6

ER -