Evaluation of cell function upon nanovector internalization

Jonathan O. Martinez, Alessandro Parodi, Xuewu Liu, Mikhail G. Kolonin, Mauro Ferrari, Ennio Tasciotti

Research output: Contribution to journalArticle

Abstract

In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

Original languageEnglish
Pages (from-to)1696-1702
Number of pages7
JournalSmall
Volume9
Issue number9-10
DOIs
Publication statusPublished - May 27 2013

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Keywords

  • biocompatibility
  • cytotoxicity
  • mesoporous materials
  • nanomaterials
  • nanotechnology

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Martinez, J. O., Parodi, A., Liu, X., Kolonin, M. G., Ferrari, M., & Tasciotti, E. (2013). Evaluation of cell function upon nanovector internalization. Small, 9(9-10), 1696-1702. https://doi.org/10.1002/smll.201202001