TY - JOUR
T1 - Evaluation of cellular immune responses and soluble mediators in patients with chronic hepatitis c virus (CHCV) infection
AU - Jirillo, Emilio
AU - Greco, Beatrice
AU - Caradonna, Luigi
AU - Satalino, Rosa
AU - Pugliese, Vittorio
AU - Cozzolongo, Raffaele
AU - Cuppone, Renato
AU - Manghisi, Onofrio G.
PY - 1995
Y1 - 1995
N2 - In 54 patients with cHCV infection, peripheral immune responsiveness and soluble mediator release were evaluated. Results demonstrate that in these patients phagocytosis and killing capacities exerted by polymorphonuclear cells and monocytes were profoundly depressed. At the same time, absolute numbers of CD3+ CD8+ and CD16+ cells were reduced, while the CD4+ -CD8+ dependent antibacterial activity was also impaired. With special reference to soluble mediators, elevated amounts of both soluble interleukin-2 receptor and soluble intercellular adhesion molecule-1 were detected in sera of patients. By contrast, serum levels of tumor necrosis factor-α were within normal ranges, whereas interferon-γ serum concentrations were decreased. of note, in 18,5% of cHCV patients circulating levels of bacterial lipopolysaccharides (LPS) were detected by means of Limulus assay. In the Limulus + subset of patients, absolute numbers of CD14+ cells were reduced in a significant manner, this implying a putative monocyte-LPS interaction. In conclusion, the overall results indicate a condition of peripheral immune depression in cHCV patients with an exaggerated shedding of various mediators endowed with noxious effects for the host.
AB - In 54 patients with cHCV infection, peripheral immune responsiveness and soluble mediator release were evaluated. Results demonstrate that in these patients phagocytosis and killing capacities exerted by polymorphonuclear cells and monocytes were profoundly depressed. At the same time, absolute numbers of CD3+ CD8+ and CD16+ cells were reduced, while the CD4+ -CD8+ dependent antibacterial activity was also impaired. With special reference to soluble mediators, elevated amounts of both soluble interleukin-2 receptor and soluble intercellular adhesion molecule-1 were detected in sera of patients. By contrast, serum levels of tumor necrosis factor-α were within normal ranges, whereas interferon-γ serum concentrations were decreased. of note, in 18,5% of cHCV patients circulating levels of bacterial lipopolysaccharides (LPS) were detected by means of Limulus assay. In the Limulus + subset of patients, absolute numbers of CD14+ cells were reduced in a significant manner, this implying a putative monocyte-LPS interaction. In conclusion, the overall results indicate a condition of peripheral immune depression in cHCV patients with an exaggerated shedding of various mediators endowed with noxious effects for the host.
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U2 - 10.3109/08923979509019756
DO - 10.3109/08923979509019756
M3 - Article
C2 - 7650295
AN - SCOPUS:0029028203
VL - 17
SP - 347
EP - 364
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
SN - 0892-3973
IS - 2
ER -